To mitigate damage to host tissues associated with a prolonged inflammatory state, the cytokine interleukin-10 (IL-10) induces expression of a set of anti-inflammatory genes that act to inhibit expression of TLR-induced pro-inflammatory genes. While many of the IL-10-induced genes can be induced by IL-10 stimulation alone, some others, such as TNIP3, are only IL-10-inducible in the presence of concurrent TLR signaling, and are thus termed IL-10 super-induced genes. TNIP3 is part of a larger cohort of IL-10 super-induced genes, and the synergy for these genes occurs at a transcriptional level, not due to mRNA stabilization. Furthermore, these IL-10 super-induced genes can be subdivided into three distinct kinetic profiles: primary response g...
The anti-inflammatory action of IL-10 primarily consists in limiting the production of proinflammato...
The mechanisms through which the anti-inflammatory cytokine IL-10 modulates the production of multip...
L-10 is an important immunosuppressive cytokine that can down-regulate expression of other cytokines...
Interleukin-10 (IL-10) is an important anti-inflammatory cytokine acting to dampen macrophage activa...
Lipopolysaccharide (LPS) triggers innate immune responses through Toll-like receptor 4 (TLR4)-depend...
<div><p>The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflamm...
IL-10 plays a central nonredundant role in limiting inflammation in vivo. However, the mechanisms in...
IL-10 plays a central nonredundant role in limiting inflammation in vivo. However, the mechanisms in...
Interleukin 10 has proven itself to be an important regulator of inflammation with a wide range of b...
IL-10 is a potent anti-inflammatory and immunosuppressive cytokine, which regulates macrophages by ...
Previous studies have shown that IL-10 can induce the expression of the suppressor of cytokine signa...
The activation of TLRs by microbial molecules triggers intracellular-signaling cascades and the expr...
Interleukin-10 (IL-10) mediates an anti-inflammatory response that constrains immune responses and l...
IL-10 is a potent anti-inflammatory cytokine and inhibitor of TNF-alpha production. The molecular pa...
The inflammatory response is an important physiological mechanism for hosts’ defense against pathoge...
The anti-inflammatory action of IL-10 primarily consists in limiting the production of proinflammato...
The mechanisms through which the anti-inflammatory cytokine IL-10 modulates the production of multip...
L-10 is an important immunosuppressive cytokine that can down-regulate expression of other cytokines...
Interleukin-10 (IL-10) is an important anti-inflammatory cytokine acting to dampen macrophage activa...
Lipopolysaccharide (LPS) triggers innate immune responses through Toll-like receptor 4 (TLR4)-depend...
<div><p>The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflamm...
IL-10 plays a central nonredundant role in limiting inflammation in vivo. However, the mechanisms in...
IL-10 plays a central nonredundant role in limiting inflammation in vivo. However, the mechanisms in...
Interleukin 10 has proven itself to be an important regulator of inflammation with a wide range of b...
IL-10 is a potent anti-inflammatory and immunosuppressive cytokine, which regulates macrophages by ...
Previous studies have shown that IL-10 can induce the expression of the suppressor of cytokine signa...
The activation of TLRs by microbial molecules triggers intracellular-signaling cascades and the expr...
Interleukin-10 (IL-10) mediates an anti-inflammatory response that constrains immune responses and l...
IL-10 is a potent anti-inflammatory cytokine and inhibitor of TNF-alpha production. The molecular pa...
The inflammatory response is an important physiological mechanism for hosts’ defense against pathoge...
The anti-inflammatory action of IL-10 primarily consists in limiting the production of proinflammato...
The mechanisms through which the anti-inflammatory cytokine IL-10 modulates the production of multip...
L-10 is an important immunosuppressive cytokine that can down-regulate expression of other cytokines...