Design and Development of Reconstitutable Sustained Release Suspension of Linezolid by Spray Drying Technique

The purpose of this research work was to design and evaluation of a stable reconstitutable Sustained release suspension for pediatric and geriatric patients using spray drying techniques. Linezolid is the drug of choice in treatment of infections caused by multi-resistant bacteria. The microcapsules were prepared by spray drying method. Drug loaded microcapsule were prepared using Eudragit RS and RL100 and ethyl cellulose in three different polymer ratio. The influence of the drug to polymer ratio and feed flow rate was studied on the properties of microcapsule using a 32factorial design. The drug to polymer ratio (X1) and feed flow rate (X2) were selected as independent variable and percentage yield, particle size, encapsulation efficiency, Q6, Q8, t90% were selected as dependent variables. Regression analysis and ANOVA were performed for dependent variables. Dissolution data were fitted to various kinetic models on drug release of microcapsule. The prepared SR suspensions were evaluated for flow properties, determination of rheological and sedimentation behavior. From the factorial batches, optimize batch of microcapsules were used for preparation of reconstitutable SR suspension using various suitable suspending agents. Accelerator stability study of reconstitutable SR suspension was performed as per ICH guideline