Effect of Sida corymbosa leaf extract on the activity of serum liver enzymes of alloxan-induced diabetic albino wistar rats

This study was designed to investigate the effect of Sida corymbosa (SC) leaf extract on serum liver enzymes activity in alloxan induced diabetic albino wistar rats. A total of 30 albino wistar rats each weighing 100g were assembled and divided into 3 groups (A-C) consisting of 10 rats. Group A received SCtreatment, B received ethanol treatment while group C served as the control group. 400mg/kg of aqueous extract of SC leaf was administered orally to the rats in group A but group B received ethanol while group C received only water for 7 days. Blood samples were collected into plain containers for estimation of biochemical parameters (ALT, AST and ALP) respectively. Serum ALP, ALT and AST were analyzed using standard methods. There was a significant decrease in the mean serum activities of ALT, AST, and ALP respectively after SC administration when compared with the control group (P=0.001, 0.000, and 0.001 respectively). Again, the result showed a significant decrease in the mean weight of the albino ratspost SC administration (P=0.000). This study revealed the  deleterious effect of of SC use on the liver. Therefore, care should be taken in the use of SC in prevention and management of liver diseases especially at high therapeutic dosage level