Supplemental file(s) description: Movie S1, Movie S2, Movie S3The discovery of cell-penetrating peptides (CPPs) over three decades ago uncovered a novel method for transporting various cargoes into cells. Although promising, CPPs have several drawbacks such as rapid metabolic degradation by proteases, immunological response, undesired interactions with the biological milieu, and nephrotoxicity. Recently, the Alabi group developed the rapid assembly of sequence-defined oligothioetheramides (oligoTEAs). OligoTEAs have three distinct advantages over native peptides, including i) abiotic design to reduce proteolytic degradation and immune response, ii) backbone and pendant group access to tune interactions, and iii) diverse monomers for massive...
Motivation: The need for more effective and safer pharmaceuticals is a persistent quest. Microbial a...
The ability of cell-penetrating peptides to cross plasma membranes has been explored for various app...
Cell-penetrating peptides are able to transport a wide variety of cargo across cell membranes. Altho...
61 pagesThe discovery of the first recombinant protein Insulin has made protein therapeutics major p...
Cell penetrating peptides (CPPs) offer great potential to deliver therapeutic molecules to previousl...
Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemist...
High molecular weight biomolecules are becoming important in the development of new therapeutics. Ho...
The hydrophobic plasma membrane constitutes an indispensable barrier for cells in living animals. Al...
The fundamental element of life known to man is the gene. The information contained in genes regulat...
In response to the urgent need for new antibiotic development strategies, antimicrobial peptides (AM...
Intracellular drug delivery systems are often limited by their poor serum stability and delivery eff...
Introduction: Crossing the plasma membrane is a prerequisite for intracellular targeted drug deliver...
Oligonucleotide-based drugs hold great promise for the treatment of many types of diseases, ranging ...
Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemist...
The therapeutic perspectives of therapeutic nucleic acids and intracellularly active proteins rely o...
Motivation: The need for more effective and safer pharmaceuticals is a persistent quest. Microbial a...
The ability of cell-penetrating peptides to cross plasma membranes has been explored for various app...
Cell-penetrating peptides are able to transport a wide variety of cargo across cell membranes. Altho...
61 pagesThe discovery of the first recombinant protein Insulin has made protein therapeutics major p...
Cell penetrating peptides (CPPs) offer great potential to deliver therapeutic molecules to previousl...
Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemist...
High molecular weight biomolecules are becoming important in the development of new therapeutics. Ho...
The hydrophobic plasma membrane constitutes an indispensable barrier for cells in living animals. Al...
The fundamental element of life known to man is the gene. The information contained in genes regulat...
In response to the urgent need for new antibiotic development strategies, antimicrobial peptides (AM...
Intracellular drug delivery systems are often limited by their poor serum stability and delivery eff...
Introduction: Crossing the plasma membrane is a prerequisite for intracellular targeted drug deliver...
Oligonucleotide-based drugs hold great promise for the treatment of many types of diseases, ranging ...
Thesis: Ph. D. in Biological Chemistry, Massachusetts Institute of Technology, Department of Chemist...
The therapeutic perspectives of therapeutic nucleic acids and intracellularly active proteins rely o...
Motivation: The need for more effective and safer pharmaceuticals is a persistent quest. Microbial a...
The ability of cell-penetrating peptides to cross plasma membranes has been explored for various app...
Cell-penetrating peptides are able to transport a wide variety of cargo across cell membranes. Altho...