CYP4Fサブファミリー(ロイコトリエンB_4ω水酸化酵素)

Leukotriene B_4 ω-hydroxylation was reported in 1981 immediately after discovery of leukotriene B_4. After that, a large number of investigations about leukotriene B_4 ω-hydroxylase in neutrophils and liver have been presented. The primary structures of the enzymes were clarified by cDNA cloning, and they were found to be novel P450s which belong to the CYP4F subfamily. At present, seventeen members of this subfamily have been discovered by cDNA cloning and by genome projects. Most of them show leukotriene B_4 ω-hydroxylase activity, and catalyze hydroxylation of various substrates including lipoxygenase dependent arachidonate metabolites, prostaglandins, and drugs. They also distribute a variety of tissues such as leukocyte, liver, kidney, seminal vesicles, and brain. Now, CYP4F enzymes are thought to have various functions