T lymphocytes are integral cells of the adaptive immune system. They respond to a wide variety of pathogens to induce humoral immunity, kill infected host cells and provide long-lasting memory for the host organism. The development and activation of T cells has been well studied, however, numerous questions remain about the details of these processes. The ERK-MAPK pathway is a signaling cascade that has been shown to play a critical role in T lymphocyte development and function. Aside from the core kinase components (Raf/MEK/ERK), numerous proteins exist to modulate the MAPK pathway, influencing the duration and localization of signaling. The first part of this thesis focuses on the role of the MAPK scaffold protein Kinase Suppressor of Ras...
BACKGROUND: The thymus constitutes the primary lymphoid organ for the majority of T cells. The phosp...
The present study has examined the role of the serine/threonine kinase LKB1 in the survival and diff...
The present study has examined the role of the serine/threonine kinase LKB1 in the survival and diff...
T lymphocytes are integral cells of the adaptive immune system. They respond to a wide variety of pa...
SummaryActivation of extracellular-signal-regulated protein kinase (Erk) is central to growth-factor...
The mammalian target of rapamycin (mTOR) kinase is a critical regulator of the differentiation of he...
<div><p>The mammalian target of rapamycin (mTOR) kinase is a critical regulator of the differentiati...
<div><p>The classical mitogen-activated protein kinases (MAPKs) ERK1 and ERK2 are activated upon sti...
The classical mitogen-activated protein kinases (MAPKs) ERK1 and ERK2 are activated upon stimulation...
International audienceSignals initiated through the TCR during development can result in either surv...
AbstractClonal selection of T lymphocytes is essential for establishing self/non-self discrimination...
AbstractClonal selection of T lymphocytes is essential for establishing self/non-self discrimination...
Thymocytes are subjected to processes of selection during their life in the thymus; negative selecti...
The Erk (Extracellular signal-regulated protein kinase) signaling pathway is thought to be critical ...
The Ras/Erk MAPK pathway has been shown to be important in multiple developmental contexts. The dev...
BACKGROUND: The thymus constitutes the primary lymphoid organ for the majority of T cells. The phosp...
The present study has examined the role of the serine/threonine kinase LKB1 in the survival and diff...
The present study has examined the role of the serine/threonine kinase LKB1 in the survival and diff...
T lymphocytes are integral cells of the adaptive immune system. They respond to a wide variety of pa...
SummaryActivation of extracellular-signal-regulated protein kinase (Erk) is central to growth-factor...
The mammalian target of rapamycin (mTOR) kinase is a critical regulator of the differentiation of he...
<div><p>The mammalian target of rapamycin (mTOR) kinase is a critical regulator of the differentiati...
<div><p>The classical mitogen-activated protein kinases (MAPKs) ERK1 and ERK2 are activated upon sti...
The classical mitogen-activated protein kinases (MAPKs) ERK1 and ERK2 are activated upon stimulation...
International audienceSignals initiated through the TCR during development can result in either surv...
AbstractClonal selection of T lymphocytes is essential for establishing self/non-self discrimination...
AbstractClonal selection of T lymphocytes is essential for establishing self/non-self discrimination...
Thymocytes are subjected to processes of selection during their life in the thymus; negative selecti...
The Erk (Extracellular signal-regulated protein kinase) signaling pathway is thought to be critical ...
The Ras/Erk MAPK pathway has been shown to be important in multiple developmental contexts. The dev...
BACKGROUND: The thymus constitutes the primary lymphoid organ for the majority of T cells. The phosp...
The present study has examined the role of the serine/threonine kinase LKB1 in the survival and diff...
The present study has examined the role of the serine/threonine kinase LKB1 in the survival and diff...