International audienceAluminium (Al) oxyhydroxide (Alhydrogel®), the main adjuvant licensed for human andanimal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concernsabout its safety emerged following recognition of its unexpectedly long-lasting biopersistencewithin immune cells in some individuals, and reports of chronic fatigue syndrome, cognitivedysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporallylinked to multiple Al-containing vaccine administrations. Mouse experiments havedocumented its capture and slow transportation by monocyte-lineage cells from the injectedmuscle to lymphoid organs and eventually the brain. The present study aimed at evaluatingmouse brain function and Al ...