International audienceIdentification and characterization of CD8+ and CD4+ T-cell epitopes elicited by HIV therapeutic vaccination is key for elucidating the nature of protective cellular responses and mechanism of the immune evasion of HIV. Here, we report the characterization of HIV-specific T-cell responses in cART (combination antiretroviral therapy) treated HIV-1 infected patients after vaccination with ex vivo-generated IFNα Dendritic Cells (DCs) loaded with LIPO-5 (HIV-1 Nef 66-97, Nef 116-145, Gag 17-35, Gag 253-284 and Pol 325-355 lipopeptides). Vaccination induced and/or expanded HIV-specific CD8+ T cells producing IFNγ, perforin, granzyme A and granzyme B, and also CD4+ T cells secreting IFNγ, IL-2 and IL-13. These responses were...
The role of regulatory T cells (Tregs) in vaccination has been poorly investigated. We have reported...
Background: During early HIV-1 infection, immunodominant T cell responses to highly variable epitope...
HIV-1 infection can be controlled by anti-retroviral drug therapy, but this is a lifetime treatment ...
International audienceIdentification and characterization of CD8+ and CD4+ T-cell epitopes elicited ...
Efforts aimed at restoring robust immune responses limiting human immunodeficiency virus (HIV)-1 rep...
Recall T cell responses to HIV-1 antigens are used as a surrogate for endogenous cellular immune res...
During acute HIV-1 infection (AHI), CD8+ T cell responses are initially induced to only 1-3 viral e...
Dendritic cells (DCs) are professional antigen-presenting cells of the immune system with the abilit...
HIV-1 remains sequestered during antiretroviral therapy (ART) and can resume high-level replication ...
International audienceThe role of regulatory T cells (Tregs) in vaccination has been poorly investig...
The role of regulatory T cells (Tregs) in vaccination has been poorly investigated. We have reported...
Background: In an effort to raise protective antiviral immunity, dendritic cell immunotherapy was ev...
Affordable therapeutic strategies that induce sustained control of human immunodeficiency virus type...
The role of regulatory T cells (Tregs) in vaccination has been poorly investigated. We have reported...
Background: During early HIV-1 infection, immunodominant T cell responses to highly variable epitope...
HIV-1 infection can be controlled by anti-retroviral drug therapy, but this is a lifetime treatment ...
International audienceIdentification and characterization of CD8+ and CD4+ T-cell epitopes elicited ...
Efforts aimed at restoring robust immune responses limiting human immunodeficiency virus (HIV)-1 rep...
Recall T cell responses to HIV-1 antigens are used as a surrogate for endogenous cellular immune res...
During acute HIV-1 infection (AHI), CD8+ T cell responses are initially induced to only 1-3 viral e...
Dendritic cells (DCs) are professional antigen-presenting cells of the immune system with the abilit...
HIV-1 remains sequestered during antiretroviral therapy (ART) and can resume high-level replication ...
International audienceThe role of regulatory T cells (Tregs) in vaccination has been poorly investig...
The role of regulatory T cells (Tregs) in vaccination has been poorly investigated. We have reported...
Background: In an effort to raise protective antiviral immunity, dendritic cell immunotherapy was ev...
Affordable therapeutic strategies that induce sustained control of human immunodeficiency virus type...
The role of regulatory T cells (Tregs) in vaccination has been poorly investigated. We have reported...
Background: During early HIV-1 infection, immunodominant T cell responses to highly variable epitope...
HIV-1 infection can be controlled by anti-retroviral drug therapy, but this is a lifetime treatment ...