Female dogs have a high incidence of mammary carcinomas which can be prevented by early spaying indicating a prominent role of ovarian steroids in the pathogenesis of mammary carcinoma. Earlier studies have revealed that exposure to progesterone or synthetic progestins results in mammary expression of the mRNAs encoding growth hormone and Wnt4. Wnt signaling plays an important role in the maintenance and activation of mammary stem cells. Canonical Wnt signaling is also upregulated in more than 50% of human and canine breast cancers. In three canine mammary tumor cell lines with an activated Wnt signaling, rounded morphology and clear stem cell properties we investigated the role of EGFR-related receptors and of cSRC on canonical Wnt activat...
Mammary tumors are the most common form of neoplasia in the bitch. Female dogs are protected when th...
Breast cancer is the most common neoplasm which is frequently diagnosed in women. One in eight women...
Breast cancer is the most common neoplasm which is frequently diagnosed in women. One in eight women...
Female dogs have a high incidence of mammary carcinomas which can be prevented by early spaying indi...
Female dogs have a high incidence of mammary carcinomas which can be prevented by early spaying indi...
Breast cancer is the most prominent cancer in women of the Western world with over 1.7 million women...
BACKGROUND: Elevated basal, ligand-independent, Wnt signaling in some canine breast cancer cells is ...
Purpose: To find underlying mutations causing highly-activated Wnt activity in mammary tumor cell li...
High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition...
Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model ...
BACKGROUND: HER2 overexpression leads to aggressive mammary tumor growth. Although the prognosis of ...
<div><p>Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a goo...
Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model ...
Mammary tumors are the most common form of neoplasia in the bitch. Female dogs are protected when th...
Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model ...
Mammary tumors are the most common form of neoplasia in the bitch. Female dogs are protected when th...
Breast cancer is the most common neoplasm which is frequently diagnosed in women. One in eight women...
Breast cancer is the most common neoplasm which is frequently diagnosed in women. One in eight women...
Female dogs have a high incidence of mammary carcinomas which can be prevented by early spaying indi...
Female dogs have a high incidence of mammary carcinomas which can be prevented by early spaying indi...
Breast cancer is the most prominent cancer in women of the Western world with over 1.7 million women...
BACKGROUND: Elevated basal, ligand-independent, Wnt signaling in some canine breast cancer cells is ...
Purpose: To find underlying mutations causing highly-activated Wnt activity in mammary tumor cell li...
High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition...
Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model ...
BACKGROUND: HER2 overexpression leads to aggressive mammary tumor growth. Although the prognosis of ...
<div><p>Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a goo...
Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model ...
Mammary tumors are the most common form of neoplasia in the bitch. Female dogs are protected when th...
Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model ...
Mammary tumors are the most common form of neoplasia in the bitch. Female dogs are protected when th...
Breast cancer is the most common neoplasm which is frequently diagnosed in women. One in eight women...
Breast cancer is the most common neoplasm which is frequently diagnosed in women. One in eight women...