Background: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disorder leading to muscle weakness and respiratory failure, with death following, on average, within three years after symptom onset. Currently, there is no effective therapy and the mainstay of care for patients with ALS aims at improving the quality of life and at the management of symptoms. Therefore, there is a pressing unmet need for effective therapy. Despite the conduct of dozens of clinical trials and promising preclinical results, none of the evaluated drugs obtained global market authorization. Objective: This thesis aims to identify and address the main bottlenecks of the clinical drug development for ALS. Methods: Part 1 of this thesis ai...
Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease...
Amyotrophic lateral sclerosis is a progressive and devastating neurodegenerative disease. Despite de...
30 p.-3 fig.-3 tab.Introduction: Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron progres...
Background: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disorder ...
Development of effective treatment for amyotrophic lateral sclerosis (ALS) has been hampered by dise...
Development of effective treatments for amyotrophic lateral sclerosis (ALS) has been hampered by dis...
Background: Funding and resources for low prevalent neurodegenerative disorders such as amyotrophic ...
Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same historica...
AbstractAmyotrophic lateral sclerosis (ALS) is a rapidly progressive, adult-onset neurodegenerative ...
Amyotrophic lateral sclerosis is a progressive and devastating neurodegenerative disease. Despite de...
textabstractObjective: Amyotrophic lateral sclerosis (ALS) clinical trials based on single end point...
Clinical trials in amyotrophic lateral sclerosis (ALS) have been conducted for over half a century n...
Background: Amyotrophic lateral sclerosis (ALS) is a disease with a widely varying prognosis. The ma...
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder with complex biolog...
International audienceIntroduction: To date, riluzole and edaravone are the only two drugs that have...
Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease...
Amyotrophic lateral sclerosis is a progressive and devastating neurodegenerative disease. Despite de...
30 p.-3 fig.-3 tab.Introduction: Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron progres...
Background: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disorder ...
Development of effective treatment for amyotrophic lateral sclerosis (ALS) has been hampered by dise...
Development of effective treatments for amyotrophic lateral sclerosis (ALS) has been hampered by dis...
Background: Funding and resources for low prevalent neurodegenerative disorders such as amyotrophic ...
Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same historica...
AbstractAmyotrophic lateral sclerosis (ALS) is a rapidly progressive, adult-onset neurodegenerative ...
Amyotrophic lateral sclerosis is a progressive and devastating neurodegenerative disease. Despite de...
textabstractObjective: Amyotrophic lateral sclerosis (ALS) clinical trials based on single end point...
Clinical trials in amyotrophic lateral sclerosis (ALS) have been conducted for over half a century n...
Background: Amyotrophic lateral sclerosis (ALS) is a disease with a widely varying prognosis. The ma...
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder with complex biolog...
International audienceIntroduction: To date, riluzole and edaravone are the only two drugs that have...
Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease...
Amyotrophic lateral sclerosis is a progressive and devastating neurodegenerative disease. Despite de...
30 p.-3 fig.-3 tab.Introduction: Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron progres...