Hydantoin derivatives and heterocyclic aldehydes may be effective in diminishing the viability of glioblastoma cells. The goal of this project is to synthesize novel thiohydantoin-aldehyde hybrid compounds and determine the effect of those compounds on glioblastoma cell viability. Compounds are synthesized using a catalyst in a reflux procedure followed by purification via extraction. Testing is performed via a three-day LD50 assay. Varying concentrations of a compound is added to a 12-well plate containing glioblastoma cells. The viability of the treated cells is then analyzed using a crystal violet stain. Several compounds have been synthesized and testing is ongoing
Mesenchymal glioblastoma stem cells (GSCs), a subpopulation in glioblastoma that are responsible for...
Glioblastoma is a malignant brain cancer responsible for taking many lives. With a high fatality rat...
Glioblastoma (GBM) is the most common and aggressive type of brain tumor in adults. The triazene Tem...
The primary objectives of this interdisciplinary study were the synthesis of novel heterocyclic aryl...
The primary objective of this research study was to investigate the efficacy of novel hybrid heteroc...
Glioblastoma has the highest incidence among brain and central nervous system cancers and is known f...
INTRODUCTION: Substituted indoles and related structures have been shown to exhibit potent anticance...
Glioblastoma (GBM), a malignant brain tumor, is one of the most aggressive human neoplasms due to it...
Glioblastoma multiforme, is a type of brain cancer that develops from glial cells, which surround ne...
This presentation discusses the progress we are making regarding the efficacy of our novel synthesiz...
The Aim of the Research: To evaluate oleanolic (3-beta-hydroxyolean-12-en-28-oic) acid (OA) effect o...
The aim of research – to investigate and compare the effect of different concentrations of three dif...
Glioblastoma (GB), a grade IV glioma, with high heterogeneity and chemoresistance, obligates a multi...
Glioblastoma, one of the most lethal forms of astrocytoma, has a median survival rate of fifteen mon...
Chromone, imidazolidinedione, thiohydantoin and 2,4-thiazolidinedione structures are known to be cyt...
Mesenchymal glioblastoma stem cells (GSCs), a subpopulation in glioblastoma that are responsible for...
Glioblastoma is a malignant brain cancer responsible for taking many lives. With a high fatality rat...
Glioblastoma (GBM) is the most common and aggressive type of brain tumor in adults. The triazene Tem...
The primary objectives of this interdisciplinary study were the synthesis of novel heterocyclic aryl...
The primary objective of this research study was to investigate the efficacy of novel hybrid heteroc...
Glioblastoma has the highest incidence among brain and central nervous system cancers and is known f...
INTRODUCTION: Substituted indoles and related structures have been shown to exhibit potent anticance...
Glioblastoma (GBM), a malignant brain tumor, is one of the most aggressive human neoplasms due to it...
Glioblastoma multiforme, is a type of brain cancer that develops from glial cells, which surround ne...
This presentation discusses the progress we are making regarding the efficacy of our novel synthesiz...
The Aim of the Research: To evaluate oleanolic (3-beta-hydroxyolean-12-en-28-oic) acid (OA) effect o...
The aim of research – to investigate and compare the effect of different concentrations of three dif...
Glioblastoma (GB), a grade IV glioma, with high heterogeneity and chemoresistance, obligates a multi...
Glioblastoma, one of the most lethal forms of astrocytoma, has a median survival rate of fifteen mon...
Chromone, imidazolidinedione, thiohydantoin and 2,4-thiazolidinedione structures are known to be cyt...
Mesenchymal glioblastoma stem cells (GSCs), a subpopulation in glioblastoma that are responsible for...
Glioblastoma is a malignant brain cancer responsible for taking many lives. With a high fatality rat...
Glioblastoma (GBM) is the most common and aggressive type of brain tumor in adults. The triazene Tem...