Add to ORKGMy research project is focused around a specific gene - cytosolic carboxypeptidase 5 (CCP5). Previous research suggests that the CCP5 gene is essential for the modification of alpha-tubulin which is necessary for normal growth of cilia in the olfactory pit of zebrafish. Using a CCP5-MO to knockdown the gene I was able to compare the resulting phenotype to that of a control specimen in order to determine any visible differences with respect to cilia morphology. Through analysis by scanning electron miscroscopy I wasw able to that cilia morphology did appear to be effected by the knockdown of CCP5. However, similar results were also displayed by one of our control groups unaffected by CCP5-MO, there fore no conclusive results could be drwan f...
<p>(A) INPP5B protein levels in HEK293T cells. <i>GFP-Inpp5b</i> lentivirus was generated in HEK293T...
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wi...
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wi...
My research project is focused around a specific gene—cytosolic carboxypeptidase 5 (CCP5). Previous ...
The cytosolic carboxypeptidases (CCPs) are a subfamily of metalloenzymes within the larger M14 famil...
Glutamylation is a functionally important tubulin posttranslational modification enriched on stable ...
<p>(A) Domain structure of human INPP5B protein. (B) hTERT-RPE1 cells were transduced by <i>GFP-Inpp...
The structure of all cilia is remarkably well conserved from single-celled organisms to mammals, and...
AbstractInositol phosphatases are important regulators of cell signaling and membrane trafficking. M...
Cilia are microtubule-based organelles that project into the extracellular space and have various fu...
Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infec...
<p>(A) <i>INPP5B</i> WT mRNA rescue the loss of <i>inpp5b</i>. KV cilia of zebrafish embryos injecte...
A) Cilia length and number in zebrafish Kupffer’s vesicles. The length and number of cilia in ttc18 ...
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wi...
Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infec...
<p>(A) INPP5B protein levels in HEK293T cells. <i>GFP-Inpp5b</i> lentivirus was generated in HEK293T...
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wi...
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wi...
My research project is focused around a specific gene—cytosolic carboxypeptidase 5 (CCP5). Previous ...
The cytosolic carboxypeptidases (CCPs) are a subfamily of metalloenzymes within the larger M14 famil...
Glutamylation is a functionally important tubulin posttranslational modification enriched on stable ...
<p>(A) Domain structure of human INPP5B protein. (B) hTERT-RPE1 cells were transduced by <i>GFP-Inpp...
The structure of all cilia is remarkably well conserved from single-celled organisms to mammals, and...
AbstractInositol phosphatases are important regulators of cell signaling and membrane trafficking. M...
Cilia are microtubule-based organelles that project into the extracellular space and have various fu...
Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infec...
<p>(A) <i>INPP5B</i> WT mRNA rescue the loss of <i>inpp5b</i>. KV cilia of zebrafish embryos injecte...
A) Cilia length and number in zebrafish Kupffer’s vesicles. The length and number of cilia in ttc18 ...
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wi...
Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infec...
<p>(A) INPP5B protein levels in HEK293T cells. <i>GFP-Inpp5b</i> lentivirus was generated in HEK293T...
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wi...
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wi...