Add to ORKGThis laboratory experiment, using proton NMR spectroscopy to determine the dissociation constant for heterocyclic bases, has been modified from a previously described experiment. A solution of a substituted pyridine is prepared using deuterium oxide (D2O) as the solvent. The pH of the solution is adjusted and proton NMR spectra are collected for a variety of pH values. The chemical shifts of the peaks in the NMR spectrum change depending on the degree of protonation of the pyridine ring. Analysis of the spectral data is used to calculate the dissociation constant of the substituted pyridine. This experiment is suitable for a variety of advanced chemistry laboratories including analytical chemistry and instrumental analysis
General Information Unless otherwise noted, all solvents were degassed by purging with nitrogen and ...
The proton magnetic resonance technique lends itself to the study of hydrogen bond equilibria. Throu...
In this chemical education research study, NMR was introduced to a group of 3 students with minor ch...
For an interdisciplinary approach on different topics of medicinal and analytical chemistry, we appl...
It can be very informative to acquire NMR spectra of a sample as a function of the solution pH. Exam...
pKa is an important property of a molecule which impacts many fields, such as drug design, catalysis...
Aqueous–organic solvent mixtures are commonly used for reactions or analyses, where the components o...
pKa is an important property of a molecule which impacts on many fields such as drug design, catalys...
Aqueous–organic solvent mixtures are commonly used for reactions or analyses, where the components o...
It can be very informative to acquire NMR spectra of a sample as a function of the solution pH. Exam...
It can be very informative to acquire NMR spectra of a sample as a function of the solution pH. Exam...
Solvents with 2H isotopes (deuterium) are frequently used in NMR spectroscopy to avoid large solvent...
Structure based drug development is currently considered to be an important strategy for drug discov...
“In Nuclear Magnetic Resonance (NMR) spectroscopy, the chemical shift and intensity of NMR signals p...
NMR titrations can be used to simultaneously determine the pKa's of mixtures of organic acids and ba...
General Information Unless otherwise noted, all solvents were degassed by purging with nitrogen and ...
The proton magnetic resonance technique lends itself to the study of hydrogen bond equilibria. Throu...
In this chemical education research study, NMR was introduced to a group of 3 students with minor ch...
For an interdisciplinary approach on different topics of medicinal and analytical chemistry, we appl...
It can be very informative to acquire NMR spectra of a sample as a function of the solution pH. Exam...
pKa is an important property of a molecule which impacts many fields, such as drug design, catalysis...
Aqueous–organic solvent mixtures are commonly used for reactions or analyses, where the components o...
pKa is an important property of a molecule which impacts on many fields such as drug design, catalys...
Aqueous–organic solvent mixtures are commonly used for reactions or analyses, where the components o...
It can be very informative to acquire NMR spectra of a sample as a function of the solution pH. Exam...
It can be very informative to acquire NMR spectra of a sample as a function of the solution pH. Exam...
Solvents with 2H isotopes (deuterium) are frequently used in NMR spectroscopy to avoid large solvent...
Structure based drug development is currently considered to be an important strategy for drug discov...
“In Nuclear Magnetic Resonance (NMR) spectroscopy, the chemical shift and intensity of NMR signals p...
NMR titrations can be used to simultaneously determine the pKa's of mixtures of organic acids and ba...
General Information Unless otherwise noted, all solvents were degassed by purging with nitrogen and ...
The proton magnetic resonance technique lends itself to the study of hydrogen bond equilibria. Throu...
In this chemical education research study, NMR was introduced to a group of 3 students with minor ch...