The development of naturally occurring compounds within a laboratory is important to society because it gives way for the mass production of a drug that has pertinent biological effects. In this research project, the ultimate goal is to create an easy, efficient, and flexible pathway to synthesizing Ninglain C, a naturally occurring compound in a marine organism. Ningalin C is part of the Ningalin family of compounds which exhibit anti-cancer activity because of their ability to reverse multi drug resistance1,3,5. Stemming from a six step process, a key intermediate, which will now be referred to as Ningalin C precursor, was synthesized. The pathway began with a commercially available compound, an analog of acetophenone, which led to the in...
Our lab. is deeply interested in the discovery and development of new reaction methodol. en route to...
Many biologically interesting compounds have been isolated from marine natural products, many of whi...
(-)-Zampanolide is a microtubule-stabilising marine natural product, with promise as a cancer drug c...
The title alkaloid 1 has been synthesized from (S)-proline (2) using a sequence of reactions involvi...
This thesis describes work attempting to synthesize and derivatize marine natural products. Chapter ...
Heterocyclic compounds have been commonly used as anti-fungal, anti-microbial, and anti-tumor drugs ...
A flexible synthetic strategy for the total syntheses of ningalins D and G is described. The highly ...
The total synthesis of natural products and their analogs is a very exciting and challenging area of...
Natural products play a central role in drug discovery. The Andersen lab focuses its efforts on the ...
Marine natural products possess diverse architectures and pharmacology, and have provided scientists...
The development of efficient strategies for the synthesis of complex organic molecular architectures...
In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring ...
A concise total synthesis of lamellarins D (7 steps), H (7 steps), and R (5 steps) and ningalin B (5...
Marine natural products have long served as promising compounds and scaffolds for new therapeutic ag...
This dissertation describes our efforts to develop a total synthesis of the biologically active mari...
Our lab. is deeply interested in the discovery and development of new reaction methodol. en route to...
Many biologically interesting compounds have been isolated from marine natural products, many of whi...
(-)-Zampanolide is a microtubule-stabilising marine natural product, with promise as a cancer drug c...
The title alkaloid 1 has been synthesized from (S)-proline (2) using a sequence of reactions involvi...
This thesis describes work attempting to synthesize and derivatize marine natural products. Chapter ...
Heterocyclic compounds have been commonly used as anti-fungal, anti-microbial, and anti-tumor drugs ...
A flexible synthetic strategy for the total syntheses of ningalins D and G is described. The highly ...
The total synthesis of natural products and their analogs is a very exciting and challenging area of...
Natural products play a central role in drug discovery. The Andersen lab focuses its efforts on the ...
Marine natural products possess diverse architectures and pharmacology, and have provided scientists...
The development of efficient strategies for the synthesis of complex organic molecular architectures...
In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring ...
A concise total synthesis of lamellarins D (7 steps), H (7 steps), and R (5 steps) and ningalin B (5...
Marine natural products have long served as promising compounds and scaffolds for new therapeutic ag...
This dissertation describes our efforts to develop a total synthesis of the biologically active mari...
Our lab. is deeply interested in the discovery and development of new reaction methodol. en route to...
Many biologically interesting compounds have been isolated from marine natural products, many of whi...
(-)-Zampanolide is a microtubule-stabilising marine natural product, with promise as a cancer drug c...