Crystal structures for the commercial monohydrate form and an anhydrate form of dasatinib, an oral anti-cancer agent, are presented along with characterization by Raman spectroscopy, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. Solubility measurements conducted in water reveal the anhydrate has dramatically improved solubility compared to the commercial hydrate form. Finally, dasatinib is a rare example of a promiscuous solvate former and the basis for this behavior can now be understood by examining the poor packing efficiency in the unsolvated form
The crystal structures of the monohydrate and anhydrous forms of ambazone were determined by single-...
The crystal structures of the monohydrate and anhydrous forms of ambazone were determined by single-...
A new polymorph and three hydrates of baicalein, a widely prescribed anti-inflammatory TCM drug, wer...
Crystal structures for the commercial monohydrate form and an anhydrate form of dasatinib, an oral a...
Crystal structures for the commercial monohydrate form and an anhydrate form of dasatinib, an oral a...
Apatinib (APA) is a targeted anti-neoplastic drug by inhibiting the vascular endothelial cell growth...
International audienceA complete solid-state study of the drug quinacrine dihydrochloride has highli...
Purpose. To study the desolvation/solvation mechanism and kinetics of TMC114 (PrezistaTM, Darunavir)...
TMC114 (PrezistaTM, Darunavir), a next-generation, synthetic nonpeptidic protease inhibitor, is a ke...
Crystal polymorphism and solvent inclusion are a dominant research area in the pharmaceutical indust...
Understanding the properties of solid-state compounds, especially solvated drugs, is very important ...
More than 50% of active pharmaceutical ingredients (APIs) are crystallized as simple salts, and of t...
AZD9898 has previously been used as a candidate for a potentially active pharmaceutical ingredient. ...
Crystal polymorphism and solvent inclusion are a dominant research area in the pharmaceutical indust...
More than 50% of active pharmaceutical ingredients (APIs) are crystallized as simple salts, and of t...
The crystal structures of the monohydrate and anhydrous forms of ambazone were determined by single-...
The crystal structures of the monohydrate and anhydrous forms of ambazone were determined by single-...
A new polymorph and three hydrates of baicalein, a widely prescribed anti-inflammatory TCM drug, wer...
Crystal structures for the commercial monohydrate form and an anhydrate form of dasatinib, an oral a...
Crystal structures for the commercial monohydrate form and an anhydrate form of dasatinib, an oral a...
Apatinib (APA) is a targeted anti-neoplastic drug by inhibiting the vascular endothelial cell growth...
International audienceA complete solid-state study of the drug quinacrine dihydrochloride has highli...
Purpose. To study the desolvation/solvation mechanism and kinetics of TMC114 (PrezistaTM, Darunavir)...
TMC114 (PrezistaTM, Darunavir), a next-generation, synthetic nonpeptidic protease inhibitor, is a ke...
Crystal polymorphism and solvent inclusion are a dominant research area in the pharmaceutical indust...
Understanding the properties of solid-state compounds, especially solvated drugs, is very important ...
More than 50% of active pharmaceutical ingredients (APIs) are crystallized as simple salts, and of t...
AZD9898 has previously been used as a candidate for a potentially active pharmaceutical ingredient. ...
Crystal polymorphism and solvent inclusion are a dominant research area in the pharmaceutical indust...
More than 50% of active pharmaceutical ingredients (APIs) are crystallized as simple salts, and of t...
The crystal structures of the monohydrate and anhydrous forms of ambazone were determined by single-...
The crystal structures of the monohydrate and anhydrous forms of ambazone were determined by single-...
A new polymorph and three hydrates of baicalein, a widely prescribed anti-inflammatory TCM drug, wer...