Human pancreas organoids are a promising cell therapy candidate for Type I Diabetes Mellitus (T1DM). T1DM is a disabling chronic disease with a juvenile onset. Auto-immune destruction of pancreatic beta cells results in insufficient insulin production to manage blood glucose. This can lead, on the long-term, to serious complications, such as hypoglycemic episodes, neuropathy, retinopathy, and renal failure. The current standard of care is insulin therapy. However this cannot fully prevent long-term complications from arising, especially in patients suffering from uncontrolled T1DM with severe hypoglycemic episodes. Restoration of the natural blood glucose management can prevent complications, for instance by restoring the beta cell populati...
Diabetes mellitus is a chronic disease that affects hundreds of millions of people worldwide. Type 1...
Summary: Generating an unlimited source of human insulin-producing cells is a prerequisite to advanc...
Type I diabetes mellitus is a metabolic disorder caused by an autoimmune destruction of the insulin-...
For a small patient group with type 1 diabetes (T1D), standard treatment with insulin is very diffic...
Encapsulating, or immunoisolating, insulin-secreting cells within implantable, semipermeable membran...
Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use...
The current treatment approach for type 1 diabetes is based on daily insulin injections, combined wi...
The current treatment approach for type 1 diabetes is based on daily insulin injections, combined wi...
T1D consists of selective autoimmune killing of pancreatic islet β-cells that physiologically accomp...
The incidence of diabetes mellitus has grown exponentially in the last few years. Etiopathogenesis o...
The capacity of organoids to generate complex 3D structures resembling organs is revolutionizing the...
Complications associated with type 1 diabetes mellitus (T1DM) are a major health care problem worldw...
Type 1 diabetes is a disease resulting from autoimmune destruction of the insulin-producing beta cel...
The number of cell and gene therapy products approved in North America now exceeds 15, creating a ne...
Exogenous insulin is, at the moment, the therapy of choice of diabetes, but does not allow tight reg...
Diabetes mellitus is a chronic disease that affects hundreds of millions of people worldwide. Type 1...
Summary: Generating an unlimited source of human insulin-producing cells is a prerequisite to advanc...
Type I diabetes mellitus is a metabolic disorder caused by an autoimmune destruction of the insulin-...
For a small patient group with type 1 diabetes (T1D), standard treatment with insulin is very diffic...
Encapsulating, or immunoisolating, insulin-secreting cells within implantable, semipermeable membran...
Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use...
The current treatment approach for type 1 diabetes is based on daily insulin injections, combined wi...
The current treatment approach for type 1 diabetes is based on daily insulin injections, combined wi...
T1D consists of selective autoimmune killing of pancreatic islet β-cells that physiologically accomp...
The incidence of diabetes mellitus has grown exponentially in the last few years. Etiopathogenesis o...
The capacity of organoids to generate complex 3D structures resembling organs is revolutionizing the...
Complications associated with type 1 diabetes mellitus (T1DM) are a major health care problem worldw...
Type 1 diabetes is a disease resulting from autoimmune destruction of the insulin-producing beta cel...
The number of cell and gene therapy products approved in North America now exceeds 15, creating a ne...
Exogenous insulin is, at the moment, the therapy of choice of diabetes, but does not allow tight reg...
Diabetes mellitus is a chronic disease that affects hundreds of millions of people worldwide. Type 1...
Summary: Generating an unlimited source of human insulin-producing cells is a prerequisite to advanc...
Type I diabetes mellitus is a metabolic disorder caused by an autoimmune destruction of the insulin-...