Synthesis, photophysical and DNA binding studies of novel pyridinium based 1 ,8-naphthalimide derivatives

THESIS 10008This thesis entitled "Synthesis, Photophysical and DNA Binding Studies of Novel Pyridinium Based 1,8-Naphthalimide Derivatives" is divided into six chapters. Chapter 1 is the introductory chapter, which provides a brief introduction to the cell cycle and how misregulation of cell cycle can lead to cancer development. This is followed by a brief description of the DNA structure, different binding modes by which small molecules can interact with DNA and a summary of various methods widely used to probe drug-DNA interactions. The development of various antitumour agents based on the 1,8- naphthalimide structure is presented citing relevant examples from the literature and also work performed within the Gunnlaugsson group. The photophysical properties of various 1,8-naphthalimide derivatives are also discussed