Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telomere. Both oxidative stress and telomere shortening/dysfunction cause aging-related degenerative pathologies and increase cancer risk. However, a direct connection between oxidative damage to telomeric DNA, comprising \u3c1% of the genome, and telomere dysfunction has not been established. By fusing the KillerRed chromophore with the telomere repeat binding factor 1, TRF1, we developed a novel approach to generate localized damage to telomere DNA and to monitor the real time damage response at the single telomere level. We found that DNA damage at long telomeres in U2OS cells is not repaired efficiently compared to DNA damage in non-telomeric ...
Telomeres are specialized nucleoprotein structures, which protect chromosome ends and have been impl...
Cells are often subjected to the effect of reactive oxygen species (ROS) as a result of both intrace...
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Te...
Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telom...
Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telom...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Biochemistry and B...
The ends of linear chromosomes are capped by protein–DNA complexes termed telomeres. Telomere repeat...
Oxidative DNA damage, particularly 8-oxoguanine, represents the most frequent DNA damage in human ce...
One main function of telomeres is to maintain chromosome and genome stability. The rate of telomere ...
One main function of telomeres is to maintain chromosome and genome stability. The rate of telomere ...
One main function of telomeres is to maintain chromosome and genome stability. The rate of telomere ...
Linear genomes end in characteristic structures consisting of repetitive DNA and proteins: the telom...
AbstractWe report cytologic and genetic data indicating that telomere dysfunction induces a DNA dama...
Telomere are composed of G rich nucleotide (TTAGGG)n typically 20 kb in length, are the regions of r...
Telomeres are nucleoprotein structures that contain non-coding (TTAGGG) tandem repeats and associate...
Telomeres are specialized nucleoprotein structures, which protect chromosome ends and have been impl...
Cells are often subjected to the effect of reactive oxygen species (ROS) as a result of both intrace...
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Te...
Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telom...
Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telom...
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Biochemistry and B...
The ends of linear chromosomes are capped by protein–DNA complexes termed telomeres. Telomere repeat...
Oxidative DNA damage, particularly 8-oxoguanine, represents the most frequent DNA damage in human ce...
One main function of telomeres is to maintain chromosome and genome stability. The rate of telomere ...
One main function of telomeres is to maintain chromosome and genome stability. The rate of telomere ...
One main function of telomeres is to maintain chromosome and genome stability. The rate of telomere ...
Linear genomes end in characteristic structures consisting of repetitive DNA and proteins: the telom...
AbstractWe report cytologic and genetic data indicating that telomere dysfunction induces a DNA dama...
Telomere are composed of G rich nucleotide (TTAGGG)n typically 20 kb in length, are the regions of r...
Telomeres are nucleoprotein structures that contain non-coding (TTAGGG) tandem repeats and associate...
Telomeres are specialized nucleoprotein structures, which protect chromosome ends and have been impl...
Cells are often subjected to the effect of reactive oxygen species (ROS) as a result of both intrace...
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Te...