Add to ORKGPharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) having selective antagonist properties at α3β2-containing nicotinic receptor subtypes, and compositions containing these compounds. The compounds and compositions are used to treat central nervous system pathologies
Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder...
This project utilized synthesis and in vitro assays to generate antagonist SARs at various nAChR sub...
Neuronal nicotinic acetylcholine receptors (nAChRs) make up a family of pentameric ligand-gated ion ...
Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, add...
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neu...
Nicotine analogs that have nicotinic receptor antagonist properties. These compounds have been shown...
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylch...
Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine ...
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine rec...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
The current project examined the ability of a novel series of guandine and amidine-containing nicoti...
Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands i...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Compounds are disclosed comprising molecular adjuvants having an antigen presenting cell-targeting l...
Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder...
This project utilized synthesis and in vitro assays to generate antagonist SARs at various nAChR sub...
Neuronal nicotinic acetylcholine receptors (nAChRs) make up a family of pentameric ligand-gated ion ...
Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, add...
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neu...
Nicotine analogs that have nicotinic receptor antagonist properties. These compounds have been shown...
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylch...
Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine ...
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine rec...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
The current project examined the ability of a novel series of guandine and amidine-containing nicoti...
Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands i...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Compounds are disclosed comprising molecular adjuvants having an antigen presenting cell-targeting l...
Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder...
This project utilized synthesis and in vitro assays to generate antagonist SARs at various nAChR sub...
Neuronal nicotinic acetylcholine receptors (nAChRs) make up a family of pentameric ligand-gated ion ...