Add to ORKGNicotine analogs that have nicotinic receptor antagonist properties. These compounds have been shown to competitively inhibit dopamine release induced by nicotine. The nicotine analog compounds are useful in the treatment of nicotine abuse, smoking cessation therapy, as an antidote for nicotine intoxication, treatment of cognitive disorders such as Alzheimer\u27s disease and for the treatment of Parkinson\u27s disease
We here have addressed the topic of the cross-talk between receptors. We provide evidence supporting...
Cognitive dysfunction is evident in a wide variety of neurological disorders from schizophrenia to ...
Nicotinic acetylcholine receptors (nAChRs) are pentameric, ligand-gated, cation channels found throu...
Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, add...
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neu...
Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) havi...
Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder...
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine ...
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine rec...
The current project examined the ability of a novel series of guandine and amidine-containing nicoti...
There is a need for different and better aids to tobacco product use cessation. Useful smoking cessa...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands i...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
We here have addressed the topic of the cross-talk between receptors. We provide evidence supporting...
Cognitive dysfunction is evident in a wide variety of neurological disorders from schizophrenia to ...
Nicotinic acetylcholine receptors (nAChRs) are pentameric, ligand-gated, cation channels found throu...
Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, add...
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neu...
Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) havi...
Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder...
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine ...
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine rec...
The current project examined the ability of a novel series of guandine and amidine-containing nicoti...
There is a need for different and better aids to tobacco product use cessation. Useful smoking cessa...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands i...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
We here have addressed the topic of the cross-talk between receptors. We provide evidence supporting...
Cognitive dysfunction is evident in a wide variety of neurological disorders from schizophrenia to ...
Nicotinic acetylcholine receptors (nAChRs) are pentameric, ligand-gated, cation channels found throu...