Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, addiction to opiates, addiction to alcohol, addiction to tobacco products, addiction to nicotine, schizophrenia and related diseases, depression and related conditions, Alzheimer\u27s disease, Parkinson\u27s disease, irritable bowel syndrome, and colitis. The compounds competitively inhibit central nervous system acting nicotinic receptor agonists and act at the putative α3β2* and α4β2 neuronal nicotinic receptors in the central nervous system
The current project examined the ability of a novel series of guandine and amidine-containing nicoti...
Compounds are disclosed comprising molecular adjuvants having an antigen presenting cell-targeting l...
This project utilized synthesis and in vitro assays to generate antagonist SARs at various nAChR sub...
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neu...
Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) havi...
Nicotine analogs that have nicotinic receptor antagonist properties. These compounds have been shown...
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine rec...
Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder...
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylch...
Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine ...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands i...
Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula... To see t...
The current project examined the ability of a novel series of guandine and amidine-containing nicoti...
Compounds are disclosed comprising molecular adjuvants having an antigen presenting cell-targeting l...
This project utilized synthesis and in vitro assays to generate antagonist SARs at various nAChR sub...
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neu...
Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) havi...
Nicotine analogs that have nicotinic receptor antagonist properties. These compounds have been shown...
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine rec...
Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder...
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylch...
Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine ...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands i...
Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula... To see t...
The current project examined the ability of a novel series of guandine and amidine-containing nicoti...
Compounds are disclosed comprising molecular adjuvants having an antigen presenting cell-targeting l...
This project utilized synthesis and in vitro assays to generate antagonist SARs at various nAChR sub...