Add to ORKGProvided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders
Nicotinic acetylcholine receptors (nAChR) are part of the Cys-loop family of ligand-gated ion channe...
Photoactivatable pharmacological agents have revolutionized neuroscience, but the palette of availab...
The nicotinic stimulating and paralyzing properties of the aliphatic quaternary ammonium derivatives...
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine rec...
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylch...
Nicotine analogs that have nicotinic receptor antagonist properties. These compounds have been shown...
Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, add...
Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) havi...
Provided are tris-quatemary ammonium compounds which are modulators of nociception and pain
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neu...
Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder...
This project utilized synthesis and in vitro assays to generate antagonist SARs at various nAChR sub...
Nicotinic acetylcholine receptors (nAChR) are part of the Cys-loop family of ligand-gated ion channe...
Photoactivatable pharmacological agents have revolutionized neuroscience, but the palette of availab...
The nicotinic stimulating and paralyzing properties of the aliphatic quaternary ammonium derivatives...
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine recep...
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine rec...
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylch...
Nicotine analogs that have nicotinic receptor antagonist properties. These compounds have been shown...
Compounds for treating abuse of nicotinic receptor agonists, addiction to psychostimulant drugs, add...
Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) havi...
Provided are tris-quatemary ammonium compounds which are modulators of nociception and pain
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neu...
Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder...
This project utilized synthesis and in vitro assays to generate antagonist SARs at various nAChR sub...
Nicotinic acetylcholine receptors (nAChR) are part of the Cys-loop family of ligand-gated ion channe...
Photoactivatable pharmacological agents have revolutionized neuroscience, but the palette of availab...
The nicotinic stimulating and paralyzing properties of the aliphatic quaternary ammonium derivatives...