The current project examined the ability of nicotine to modulate dopamine transporter (DAT) function. Initial experiments determined the dose-response for nicotine to modulate dopamine (DA) clearance in rat striatum and medial prefrontal cortex (MPFC) using in vivo voltammetry and determined if this effect was mediated by nicotinic receptors (nAChRs). In both striatum and MPFC, nicotine increased DA clearance in a mecamylamine-sensitive manner, indicating nAChR-mediation. The effect of acute nornicotine on DAT function was also determined. In contrast to nicotine, nornicotine in a dose-related manner decreased striatal DA clearance in a mecamylamine-sensitive manner, indicating nAChR mediation. To determine if tolerance developed to the nic...
Current concepts concerning nicotine\u27s central nervous system (CNS) mechanism(s) of action sugges...
Tobacco smoking is associated with increased risk for dependence and reduced risk for Parkinson’s di...
We here have addressed the topic of the cross-talk between receptors. We provide evidence supporting...
The current project examined the ability of nicotine to modulate dopamine transporter (DAT) function...
current project examined the ability of nicotine to modulate dopamine transporter (DAT) function. In...
With the growing number of individuals regularly using e-cigarettes, it has become increasingly impo...
Nicotine is a highly addictive drug and exerts this effect partially through the modulation of dopam...
Cigarette smoking causes nearly 6 million deaths worldwide every year (WHO, 2011). Current smoking c...
We investigated the physiological role of native low- and high-affinity nicotinic acetylcholine rece...
Nicotine is considered the main dependence-producing constituent in tobacco products. In analogy wit...
These electrophysiological experiments, in slices and intact animals, study the effects of in vivo c...
The neurons of the mesocorticolimbic dopamine system are located in the ventral tegmental area (VTA)...
Neonatal quinpirole (NQ) treatment to rats increases dopamine D2 receptor sensitivity persistent thr...
This dissertation represents some of the first work to investigate how acute and chronic nicotine tr...
Nicotine directly regulates striatal dopamine (DA) neurotransmission via presynaptic nicotinic acety...
Current concepts concerning nicotine\u27s central nervous system (CNS) mechanism(s) of action sugges...
Tobacco smoking is associated with increased risk for dependence and reduced risk for Parkinson’s di...
We here have addressed the topic of the cross-talk between receptors. We provide evidence supporting...
The current project examined the ability of nicotine to modulate dopamine transporter (DAT) function...
current project examined the ability of nicotine to modulate dopamine transporter (DAT) function. In...
With the growing number of individuals regularly using e-cigarettes, it has become increasingly impo...
Nicotine is a highly addictive drug and exerts this effect partially through the modulation of dopam...
Cigarette smoking causes nearly 6 million deaths worldwide every year (WHO, 2011). Current smoking c...
We investigated the physiological role of native low- and high-affinity nicotinic acetylcholine rece...
Nicotine is considered the main dependence-producing constituent in tobacco products. In analogy wit...
These electrophysiological experiments, in slices and intact animals, study the effects of in vivo c...
The neurons of the mesocorticolimbic dopamine system are located in the ventral tegmental area (VTA)...
Neonatal quinpirole (NQ) treatment to rats increases dopamine D2 receptor sensitivity persistent thr...
This dissertation represents some of the first work to investigate how acute and chronic nicotine tr...
Nicotine directly regulates striatal dopamine (DA) neurotransmission via presynaptic nicotinic acety...
Current concepts concerning nicotine\u27s central nervous system (CNS) mechanism(s) of action sugges...
Tobacco smoking is associated with increased risk for dependence and reduced risk for Parkinson’s di...
We here have addressed the topic of the cross-talk between receptors. We provide evidence supporting...