Add to ORKGComputational methods for identifying and screening the most promising drug receptor candidates in the human genome are of great interest to drug discovery researchers. Successful methods will accurately identify and narrow the field of potential drug receptor candidates. This study details one such method. The method described here begins with the assumption that novel drug receptors have high sequence similarity to established drug receptors. The similarity search program FASTA3 aligns translated sequences of the human genome to known drug receptor sequences and ranks these alignments by measuring their statistical significance. Query results returned by FASTA3 are assembled into in-silico proteins or artificially generated homologs of ...
BACKGROUND: G-protein coupled receptors (GPCRs) are involved in many different physiological process...
A biomolecular object, such as a deoxyribonucleic acid (DNA), a ribonucleic acid (RNA) or a protein ...
G protein-coupled receptors (GPCR) are integral membrane proteins mediating responses from extracell...
The odds of drug hit identification in screening are closely related to the diversity of libraries o...
The development of drugs that simultaneously target multiple receptors in a rational way (i.e., 'mag...
The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput t...
Extension of the traditional pharmacological approach of protein target classification to whole targ...
Development of homology modeling methods will remain an area of active research. These methods aim t...
As more and more evidence has become available, the link between gene and emergent disease has been ...
With the completion of the human genome project at the beginning of the 21st century, the biological...
Departament responsable de la tesi: Departament de Bioquímica i Biologia MolecularEsta tesis doctora...
Gene network inference and drug response prediction are two important problems in computational biom...
Protein classification typically uses structural, sequence, or functional similarity. Here we introd...
We consider lead discovery as active search in a space of labelled graphs. In particular, we extend ...
We employ a multi-step process which combines computational and manual filtering to identify putativ...
BACKGROUND: G-protein coupled receptors (GPCRs) are involved in many different physiological process...
A biomolecular object, such as a deoxyribonucleic acid (DNA), a ribonucleic acid (RNA) or a protein ...
G protein-coupled receptors (GPCR) are integral membrane proteins mediating responses from extracell...
The odds of drug hit identification in screening are closely related to the diversity of libraries o...
The development of drugs that simultaneously target multiple receptors in a rational way (i.e., 'mag...
The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput t...
Extension of the traditional pharmacological approach of protein target classification to whole targ...
Development of homology modeling methods will remain an area of active research. These methods aim t...
As more and more evidence has become available, the link between gene and emergent disease has been ...
With the completion of the human genome project at the beginning of the 21st century, the biological...
Departament responsable de la tesi: Departament de Bioquímica i Biologia MolecularEsta tesis doctora...
Gene network inference and drug response prediction are two important problems in computational biom...
Protein classification typically uses structural, sequence, or functional similarity. Here we introd...
We consider lead discovery as active search in a space of labelled graphs. In particular, we extend ...
We employ a multi-step process which combines computational and manual filtering to identify putativ...
BACKGROUND: G-protein coupled receptors (GPCRs) are involved in many different physiological process...
A biomolecular object, such as a deoxyribonucleic acid (DNA), a ribonucleic acid (RNA) or a protein ...
G protein-coupled receptors (GPCR) are integral membrane proteins mediating responses from extracell...