The use of α-amino-γ-lactam oligomers (Agl-αAA) as cell penetrating vectors are described in this work. These ribbon structured oligomers are able to cross the cell membrane to reach the cytosol and deliver a biologically active cargo. Unlike peptide sequences, these oligomers display a strong enzymatic resistance. A new family of α-amino-γ-lactam oligomers (Agl-βAA) obtained from conversion of /β peptide sequences are also described. Secondary structure of these molecules have been studied by NMR, FTIR, CD and XRD. These oligomers are able to adopt a stable 12-helix structure. Unexpectedly, these oligomers are soluble in aqueous mediums without any hydrophilic side chainsL’utilisation d’oligomères d’α-amino-γ-lactame (Agl-αAA) comme vecteu...
L'utilisation des oligonucléotides antisens PMO ou PNA, pour corriger les erreurs d'épissage par blo...
A novel unconventional supramolecular oligo-cationic structure (Agm6-M-PEG-OCH3) has been synthesize...
The purpose of this thesis concerned the development of two kinds of constrained oligomeric structur...
The use of α-amino-γ-lactam oligomers (Agl-αAA) as cell penetrating vectors are described in this wo...
L’utilisation d’oligomères d’α-amino-γ-lactame (Agl-αAA) comme vecteurs de pénétration intracellulai...
Les foldamères peptidomimétiques à base d’urées (oligourées) sont aujourd’hui utilisés pour mimer la...
Peptidomimetic oligourea foldamers are now used to mimic the composition and the structure of cell-p...
The synthesis of a new type of constrained dipeptide motif oligomers is described. Monomers used are...
La synthèse d'une nouvelle famille d'oligomères de motifs contraints de dipeptides est décrite dans ...
L'utilisation des oligonucléotides antisens PMO ou PNA, pour corriger les erreurs d'épissage par blo...
The therapeutic perspectives of therapeutic nucleic acids and intracellularly active proteins rely o...
Foldamers, which are folded oligomers with well-defined conformations, have been recently reported t...
Supplemental file(s) description: Movie S1, Movie S2, Movie S3The discovery of cell-penetrating pept...
There is an urgent need to develop new therapeutic strategies to fight the emergence of multidrug re...
AbstractThe development of the peptide-based vectors for the intracellular delivery of biologically ...
L'utilisation des oligonucléotides antisens PMO ou PNA, pour corriger les erreurs d'épissage par blo...
A novel unconventional supramolecular oligo-cationic structure (Agm6-M-PEG-OCH3) has been synthesize...
The purpose of this thesis concerned the development of two kinds of constrained oligomeric structur...
The use of α-amino-γ-lactam oligomers (Agl-αAA) as cell penetrating vectors are described in this wo...
L’utilisation d’oligomères d’α-amino-γ-lactame (Agl-αAA) comme vecteurs de pénétration intracellulai...
Les foldamères peptidomimétiques à base d’urées (oligourées) sont aujourd’hui utilisés pour mimer la...
Peptidomimetic oligourea foldamers are now used to mimic the composition and the structure of cell-p...
The synthesis of a new type of constrained dipeptide motif oligomers is described. Monomers used are...
La synthèse d'une nouvelle famille d'oligomères de motifs contraints de dipeptides est décrite dans ...
L'utilisation des oligonucléotides antisens PMO ou PNA, pour corriger les erreurs d'épissage par blo...
The therapeutic perspectives of therapeutic nucleic acids and intracellularly active proteins rely o...
Foldamers, which are folded oligomers with well-defined conformations, have been recently reported t...
Supplemental file(s) description: Movie S1, Movie S2, Movie S3The discovery of cell-penetrating pept...
There is an urgent need to develop new therapeutic strategies to fight the emergence of multidrug re...
AbstractThe development of the peptide-based vectors for the intracellular delivery of biologically ...
L'utilisation des oligonucléotides antisens PMO ou PNA, pour corriger les erreurs d'épissage par blo...
A novel unconventional supramolecular oligo-cationic structure (Agm6-M-PEG-OCH3) has been synthesize...
The purpose of this thesis concerned the development of two kinds of constrained oligomeric structur...