Blood leukocyte DNA methylation predicts risk of future myocardial infarction and coronary heart disease: A longitudinal study of 11,461 participants from population-based cohorts.
- Agha, G.
- Mendelson, M.M.
- Ward-Caviness, C.K.
- Joehanes, R.
- Huan, T.
- Gondalia, R.
- Salfati, E.L.
- Brody, J.A.
- Fiorito, G.
- Bressler, J.
- Chen, B.H.
- Ligthart, S.
- Guarrera, S.
- Colicino, E.
- Just, A.C.
- Wahl, S.
- Gieger, C.
- Vandiver, A.R.
- Tanaka, T.
- Hernandez, D.G.
- Pilling, L.C.
- Singleton, A.B.
- Sacerdote, C.
- Krogh, V.
- Panico, S.
- Tumino, R.
- Li, Y.
- Zhang, G.
- Stewart, J.D.
- Floyd, J.S.
- Wiggins, K.L.
- Rotter, J.I.
- Multhaup, M.
- Bakulski, K.
- Horvath, S.
- Tsao, P.S.
- Absher, D.M.
- Vokonas, P.
- Hirschhorn, J.
- Fallin, M.D.
- Liu, C.
- Bandinelli, S.
- Boerwinkle, E.
- Dehghan, A.
- Schwartz, J.D.
- Psaty, B.M.
- Feinberg, A.P.
- Hou, L.
- Ferrucci, L.
- Sotoodehnia, N.
- Matullo, G.
- Peters, A.
- Fornage, M.
- Assimes, T.L.
- Whitsel, E.A.
- Levy, D.
- Baccarelli, A.A.
DOIAbstract
Background: DNA methylation is implicated in coronary heart disease (CHD), but current evidence is based on small, cross-sectional studies. We examined blood DNA methylation in relation to incident CHD across multiple prospective cohorts. Methods: Nine population-based cohorts from the United States and Europe profiled epigenome-wide blood leukocyte DNA methylation using the Illumina Infinium 450k microarray, and prospectively ascertained CHD events including coronary insufficiency/unstable angina, recognized myocardial infarction, coronary revascularization, and coronary death. Cohorts conducted race-specific analyses adjusted for age, sex, smoking, education, body mass index, blood cell type proportions, and technical variables. We conduc...
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