Metabolic Changes with Base-Loading in CKD
- Scialla, Julia J.
- Brown, Landon
- Gurley, Susan
- Corcoran, David L.
- Bain, James R.
- Muehlbauer, Michael J.
- O’Neal, Sara K.
- M. O’Connell, Thomas
- Wolf, Myles
- Melamed, Michal L.
- Hostetter, Thomas H.
- Abramowitz, Matthew K.
DOIAbstract
In small, randomized studies, treatment with sodium bicarbonate slowed kidney function decline in patients with CKD, possibly by lowering urine ammonium or inhibiting the renin-angiotensin-aldosterone or endothelin-1 pathways (1). Understanding the metabolic effects of alkali supplementation may reveal new candidate mechanisms. With this goal in mind, we profiled changes in systemic metabolites after treatment with sodium bicarbonate within a previously performed crossover trial of oral sodium bicarbonate (2)
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