Direct and highly stereoselective synthesis of quinolizidine iminosugars promoted by L-proline-Et3N
- Yuan, Wen
- Pan, Yang
- Zhang, Xiaoke
- Liang, Peng
- Zhang, Jichao
- Jiao, Wei
- Shao, Huawu
Publication date
December 2019
DOI Publisher
Royal Society of Chemistry (RSC)Abstract
A mild and effective method for the synthesis of polyhydroxylated quinolizidine iminosugars is described. The Mannich-type reaction of iminosugar C-glycosides with aldehyde in the presence of L-proline-Et3N provides polyhydroxylated quinolizidine iminosugars, and desired products as the potential glucosidase inhibitors were obtained in good to excellent yields with excellent stereoselectivity
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