Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

Image_1_DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination.tif

Alessandra Merlini (13528870)
Maria Laura Centomo (13528873)
Giulio Ferrero (2826245)
Giulia Chiabotto (3154371)
Umberto Miglio (4347994)
Enrico Berrino (4348003)
Giorgia Giordano (13528876)
Silvia Brusco (13528879)
Alberto Pisacane (8465721)
Elena Maldi (8465712)
Ivana Sarotto (47459)
Federica Capozzi (3987962)
Cristina Lano (13528882)
Claudio Isella (93680)
Giovanni Crisafulli (402112)
Massimo Aglietta (3457646)
Angelo Paolo Dei Tos (10747304)
Marta Sbaraglia (8713434)
Dario Sangiolo (3987992)
Lorenzo D’Ambrosio (3988025)
Alberto Bardelli (163979)
Ymera Pignochino (3987968)
Giovanni Grignani (3987965)

August 2022

BackgroundAdvanced and unresectable bone and soft tissue sarcomas (BSTS) still represent an unmet me...

A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin

Moura, David
Pena-Chilet, Maria
Cordero Varela, Juan Antonio
Alvarez-Alegret, Ramiro
Agra-Pujol, Carolina
Izquierdo, Francisco
Romagosa Pérez-Portabell, Cleofé
Valverde Morales, Claudia Maria

December 2021

Signatura genètica; Biomarcadors predictius; TrabectedinaFirma genética; Biomarcadores predictivos; ...

Trabectedin in Soft Tissue Sarcomas

Bradley Petek

February 2015

Soft tissue sarcomas are a group of rare tumors derived from mesenchymal tissue, accounting for abou...

Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

Italiano, Antoine
Touati, Nathan
Litière, Saskia
Collin, Françoise
Pourquier, Philippe
Gronchi, Alessandro

May 2018

International audienceWe describe the predictive value of BRCA1 gene status on trabectedin efficacy ...

Predictive impact of DNA repair functionality on clinical outcome of advanced sarcoma patients treated with trabectedin: a retrospective multicentric study

Schoffski, P.
Taron, M.
Jimeno, J.
Grosso, F.
Sanfilipio, R.
Casali, P. G.
Le Cesne, A.
Jones, R. L.
Blay, J. Y.
Poveda, A.
Maki, R. G.
Nieto, A.
Tercero, J. C.
Rosell, R.

May 2011

AIM: Trabectedin sensitivity is increased in cells with functional nucleotide excision DNA repair, w...

A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin.

Moura, David S
Peña-Chilet, Maria
Cordero Varela, Juan Antonio
Alvarez-Alegret, Ramiro
Agra-Pujol, Carolina
Izquierdo, Francisco
Ramos, Rafael
Ortega-Medina, Luis
Martin-Davila, Francisco
Castilla-Ramirez, Carolina
Hernandez-Leon, Carmen Nieves
Romagosa, Cleofe
Vaz Salgado, Maria Angeles
Lavernia, Javier
Bagué, Silvia
Mayodormo-Aranda, Empar
Vicioso, Luis
Hernández Barceló, Jose Emilio
Rubio-Casadevall, Jordi
de Juan, Ana
Fiaño-Valverde, Maria Concepcion
Hindi, Nadia
Lopez-Alvarez, Maria
Lacerenza, Serena
Dopazo, Joaquin
Gutierrez, Antonio
Alvarez, Rosa
Valverde, Claudia
Martinez-Trufero, Javier
Martín-Broto, Javier

June 2021

Predictive biomarkers of trabectedin represent an unmet need in advanced soft-tissue sarcomas (STS)....

BRCA1 haplotype and clinical benefit of trabectedin in soft-tissue sarcoma patients

Laroche-Clary, A
Chaire, V
Le Morvan, V
Neuville, A.
Bertucci, F.
Salas, S
Sanfilippo, R
Pourquier, Philippe
Italiano, A.

February 2015

International audienceBACKGROUND : This study aimed to determine whether the BRCA1 haplotype was ass...

Association of the germline BRCA2 missense variation Glu2663Lys with high sensitivity to trabectedin-based treatment in soft tissue sarcoma

June 2020

8noWe report an interesting clinical case of a patient carrying a specific BRCA2 germline variant af...

ERCC5/XPG, ERCC1, and BRCA1 gene status and clinical benefit of trabectedin in patients with soft tissue sarcoma.

Italiano, Antoine
Laurand, Armelle
Laroche, Audrey
Casali, Paolo
Sanfilippo, Roberta
Le Cesne, Axel
Judson, Ian
Blay, Jean-Yves
Ray-Coquard, Isabelle
Bui, Binh
Coindre, Jean-Michel
Nieto, Antonio
Tercero, Juan-Carlos
Jimeno, Jose
Robert, Jacques
Pourquier, Philippe

August 2011

International audienceBACKGROUND: The objective of this study was to determine whether specific sing...

Prospective phase II trial of trabectedin in BRCA-mutated and/or BRCAness phenotype recurrent ovarian cancer patients: the MITO 15 trial

Lorusso D
Scambia G
Pignata S
Sorio R
Amadio G
Lepori S
Mosconi A
Pisano C
Mangili G
Maltese G
Sabbatini R
Artioli G
Gamucci T
Di Napoli M
Capoluongo E
Ludovini V
Raspagliesi F
Ferrandina G

January 2016

Background: Current evidence suggest that trabectedin is particularly effective in cells lacking fun...

Trabectedin and its potential in the treatment of soft tissue sarcoma

Philippe A Cassier
Armelle Dufresne
Jean-Yves Blay
J&amp

March 2008

Philippe A Cassier1, Armelle Dufresne1, Jean-Yves Blay1,2,3, J&eacute;r&ocirc;me Fayette2,31...

DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination

Merlini, Alessandra
Centomo, Maria Laura
Ferrero, Giulio
Chiabotto, Giulia
Miglio, Umberto
Berrino, Enrico
Giordano, Giorgia
Brusco, Silvia
Pisacane, Alberto
Maldi, Elena
Sarotto, Ivana
Capozzi, Federica
Lano, Cristina
Isella, Claudio
Crisafulli, Giovanni
Aglietta, Massimo
Dei Tos, Angelo Paolo
Sbaraglia, Marta
Sangiolo, Dario
D'Ambrosio, Lorenzo
Bardelli, Alberto
Pignochino, Ymera
Grignani, Giovanni

January 2022

Advanced and unresectable bone and soft tissue sarcomas (BSTS) still represent an unmet medical need...

A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas

Le Cesne, A.
Cresta, S.
Maki, R. G.
Blay, J. Y.
Verweij, J.
Poveda, A.
Casali, P. G.
Balana, C.
Schoffski, P.
Grosso, F.
Lardelli, P.
Nieto, A.
Alfaro, V.
Demetri, G. D.

November 2012

AIMS: Approximately 20% of soft tissue sarcomas (STS) have subtype-specific chromosomal translocatio...

CUL4A, ERCC5, and ERCC1 as Predictive Factors for Trabectedin Efficacy in Advanced Soft Tissue Sarcomas (STS): A Spanish Group for Sarcoma Research (GEIS) Study

Moura, David S.
Sánchez-Bustos, Paloma
Fernández-Serra, Antonio
López-Álvarez, María
Mondaza-Hernández, José L.
Blanco-Alcaina, Elena
Gavilán-Naranjo, Ángela
Martínez-Delgado, Paula
Lacerenza, Serena
Santos-Fernández, Paloma
Carrasco-García, Irene
Hildalgo-Rios, Samuel
Gutiérrez, Antonio
Ramos, Rafael
Hindi, Nadia
Taron Roca, Miguel
López-Guerrero, José Antonio
Martín-Broto, Javier

February 2021

A translational study was designed to analyze the expression of nucleotide excision repair (NER) and...

Image_1_DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination.tif

Alessandra Merlini (13528870)
Maria Laura Centomo (13528873)
Giulio Ferrero (2826245)
Giulia Chiabotto (3154371)
Umberto Miglio (4347994)
Enrico Berrino (4348003)
Giorgia Giordano (13528876)
Silvia Brusco (13528879)
Alberto Pisacane (8465721)
Elena Maldi (8465712)
Ivana Sarotto (47459)
Federica Capozzi (3987962)
Cristina Lano (13528882)
Claudio Isella (93680)
Giovanni Crisafulli (402112)
Massimo Aglietta (3457646)
Angelo Paolo Dei Tos (10747304)
Marta Sbaraglia (8713434)
Dario Sangiolo (3987992)
Lorenzo D’Ambrosio (3988025)
Alberto Bardelli (163979)
Ymera Pignochino (3987968)
Giovanni Grignani (3987965)

August 2022

BackgroundAdvanced and unresectable bone and soft tissue sarcomas (BSTS) still represent an unmet me...

A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin

Moura, David
Pena-Chilet, Maria
Cordero Varela, Juan Antonio
Alvarez-Alegret, Ramiro
Agra-Pujol, Carolina
Izquierdo, Francisco
Romagosa Pérez-Portabell, Cleofé
Valverde Morales, Claudia Maria

December 2021

Signatura genètica; Biomarcadors predictius; TrabectedinaFirma genética; Biomarcadores predictivos; ...

Trabectedin in Soft Tissue Sarcomas

Bradley Petek

February 2015

Soft tissue sarcomas are a group of rare tumors derived from mesenchymal tissue, accounting for abou...

Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

Italiano, Antoine
Touati, Nathan
Litière, Saskia
Collin, Françoise
Pourquier, Philippe
Gronchi, Alessandro

May 2018

International audienceWe describe the predictive value of BRCA1 gene status on trabectedin efficacy ...

Predictive impact of DNA repair functionality on clinical outcome of advanced sarcoma patients treated with trabectedin: a retrospective multicentric study

Schoffski, P.
Taron, M.
Jimeno, J.
Grosso, F.
Sanfilipio, R.
Casali, P. G.
Le Cesne, A.
Jones, R. L.
Blay, J. Y.
Poveda, A.
Maki, R. G.
Nieto, A.
Tercero, J. C.
Rosell, R.

May 2011

AIM: Trabectedin sensitivity is increased in cells with functional nucleotide excision DNA repair, w...

A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin.

Moura, David S
Peña-Chilet, Maria
Cordero Varela, Juan Antonio
Alvarez-Alegret, Ramiro
Agra-Pujol, Carolina
Izquierdo, Francisco
Ramos, Rafael
Ortega-Medina, Luis
Martin-Davila, Francisco
Castilla-Ramirez, Carolina
Hernandez-Leon, Carmen Nieves
Romagosa, Cleofe
Vaz Salgado, Maria Angeles
Lavernia, Javier
Bagué, Silvia
Mayodormo-Aranda, Empar
Vicioso, Luis
Hernández Barceló, Jose Emilio
Rubio-Casadevall, Jordi
de Juan, Ana
Fiaño-Valverde, Maria Concepcion
Hindi, Nadia
Lopez-Alvarez, Maria
Lacerenza, Serena
Dopazo, Joaquin
Gutierrez, Antonio
Alvarez, Rosa
Valverde, Claudia
Martinez-Trufero, Javier
Martín-Broto, Javier

June 2021

Predictive biomarkers of trabectedin represent an unmet need in advanced soft-tissue sarcomas (STS)....

BRCA1 haplotype and clinical benefit of trabectedin in soft-tissue sarcoma patients

Laroche-Clary, A
Chaire, V
Le Morvan, V
Neuville, A.
Bertucci, F.
Salas, S
Sanfilippo, R
Pourquier, Philippe
Italiano, A.

February 2015

International audienceBACKGROUND : This study aimed to determine whether the BRCA1 haplotype was ass...

Association of the germline BRCA2 missense variation Glu2663Lys with high sensitivity to trabectedin-based treatment in soft tissue sarcoma

June 2020

8noWe report an interesting clinical case of a patient carrying a specific BRCA2 germline variant af...

ERCC5/XPG, ERCC1, and BRCA1 gene status and clinical benefit of trabectedin in patients with soft tissue sarcoma.

Italiano, Antoine
Laurand, Armelle
Laroche, Audrey
Casali, Paolo
Sanfilippo, Roberta
Le Cesne, Axel
Judson, Ian
Blay, Jean-Yves
Ray-Coquard, Isabelle
Bui, Binh
Coindre, Jean-Michel
Nieto, Antonio
Tercero, Juan-Carlos
Jimeno, Jose
Robert, Jacques
Pourquier, Philippe

August 2011

International audienceBACKGROUND: The objective of this study was to determine whether specific sing...

Prospective phase II trial of trabectedin in BRCA-mutated and/or BRCAness phenotype recurrent ovarian cancer patients: the MITO 15 trial

Lorusso D
Scambia G
Pignata S
Sorio R
Amadio G
Lepori S
Mosconi A
Pisano C
Mangili G
Maltese G
Sabbatini R
Artioli G
Gamucci T
Di Napoli M
Capoluongo E
Ludovini V
Raspagliesi F
Ferrandina G

January 2016

Background: Current evidence suggest that trabectedin is particularly effective in cells lacking fun...

Trabectedin and its potential in the treatment of soft tissue sarcoma

Philippe A Cassier
Armelle Dufresne
Jean-Yves Blay
J&amp

March 2008

Philippe A Cassier1, Armelle Dufresne1, Jean-Yves Blay1,2,3, J&eacute;r&ocirc;me Fayette2,31...

DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination

Merlini, Alessandra
Centomo, Maria Laura
Ferrero, Giulio
Chiabotto, Giulia
Miglio, Umberto
Berrino, Enrico
Giordano, Giorgia
Brusco, Silvia
Pisacane, Alberto
Maldi, Elena
Sarotto, Ivana
Capozzi, Federica
Lano, Cristina
Isella, Claudio
Crisafulli, Giovanni
Aglietta, Massimo
Dei Tos, Angelo Paolo
Sbaraglia, Marta
Sangiolo, Dario
D'Ambrosio, Lorenzo
Bardelli, Alberto
Pignochino, Ymera
Grignani, Giovanni

January 2022

Advanced and unresectable bone and soft tissue sarcomas (BSTS) still represent an unmet medical need...

A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas

Le Cesne, A.
Cresta, S.
Maki, R. G.
Blay, J. Y.
Verweij, J.
Poveda, A.
Casali, P. G.
Balana, C.
Schoffski, P.
Grosso, F.
Lardelli, P.
Nieto, A.
Alfaro, V.
Demetri, G. D.

November 2012

AIMS: Approximately 20% of soft tissue sarcomas (STS) have subtype-specific chromosomal translocatio...

CUL4A, ERCC5, and ERCC1 as Predictive Factors for Trabectedin Efficacy in Advanced Soft Tissue Sarcomas (STS): A Spanish Group for Sarcoma Research (GEIS) Study

Moura, David S.
Sánchez-Bustos, Paloma
Fernández-Serra, Antonio
López-Álvarez, María
Mondaza-Hernández, José L.
Blanco-Alcaina, Elena
Gavilán-Naranjo, Ángela
Martínez-Delgado, Paula
Lacerenza, Serena
Santos-Fernández, Paloma
Carrasco-García, Irene
Hildalgo-Rios, Samuel
Gutiérrez, Antonio
Ramos, Rafael
Hindi, Nadia
Taron Roca, Miguel
López-Guerrero, José Antonio
Martín-Broto, Javier

February 2021

A translational study was designed to analyze the expression of nucleotide excision repair (NER) and...

Image_1_DNA damage response and repair genes in advanced bone and soft tissue sarcomas: An 8-gene signature as a candidate predictive biomarker of response to trabectedin and olaparib combination.tif

Alessandra Merlini (13528870)
Maria Laura Centomo (13528873)
Giulio Ferrero (2826245)
Giulia Chiabotto (3154371)
Umberto Miglio (4347994)
Enrico Berrino (4348003)
Giorgia Giordano (13528876)
Silvia Brusco (13528879)
Alberto Pisacane (8465721)
Elena Maldi (8465712)
Ivana Sarotto (47459)
Federica Capozzi (3987962)
Cristina Lano (13528882)
Claudio Isella (93680)
Giovanni Crisafulli (402112)
Massimo Aglietta (3457646)
Angelo Paolo Dei Tos (10747304)
Marta Sbaraglia (8713434)
Dario Sangiolo (3987992)
Lorenzo D’Ambrosio (3988025)
Alberto Bardelli (163979)
Ymera Pignochino (3987968)
Giovanni Grignani (3987965)

August 2022

BackgroundAdvanced and unresectable bone and soft tissue sarcomas (BSTS) still represent an unmet me...

A DNA damage repair gene-associated signature predicts responses of patients with advanced soft-tissue sarcoma to treatment with trabectedin

Moura, David
Pena-Chilet, Maria
Cordero Varela, Juan Antonio
Alvarez-Alegret, Ramiro
Agra-Pujol, Carolina
Izquierdo, Francisco
Romagosa Pérez-Portabell, Cleofé
Valverde Morales, Claudia Maria

December 2021

Signatura genètica; Biomarcadors predictius; TrabectedinaFirma genética; Biomarcadores predictivos; ...

Trabectedin in Soft Tissue Sarcomas

Bradley Petek

February 2015

Soft tissue sarcomas are a group of rare tumors derived from mesenchymal tissue, accounting for abou...

Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

Abstract

Extracted data

Prospective assessment of the predictive value of the BRCA1 gene status in sarcoma patients treated with trabectedin: an updated analysis of the EORTC 62091 trial

Abstract

Extracted data

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