Impact of Antiretroviral Drugs on Fracture Risk in HIV-Infected Individuals: A Case–Control Study Nested Within the French Hospital Database on HIV (FHDH-ANRS CO4)

Costagliola, Dominique
Potard, Valérie
Lang, Sylvie
Abgrall, Sophie
Duvivier, Claudine
Fischer, Hugues
Joly, Véronique
Lacombe, Jean-Marc
Valantin, Marc-Antoine
Mary-Krause, Murielle
Rozenberg, Sylvie

Open link

Publication date

January 2019

DOI

10.1097/QAI.0000000000001903

Publisher

Lippincott, Williams & Wilkins

Abstract

International audienceBACKGROUND: HIV-infected patients have lower bone mineral density and a higher incidence of fractures than the general population of the same age and sex. To assess the impact of antiretroviral (ARV) drugs exposure on the risk of osteoporotic fractures, we conducted a nested case-control study.METHODS: Cases were individuals enrolled while ARV-naive, with a first prospectively recorded fracture between 2000 and 2010. Controls were randomly selected after matching for sex, age (±3 years), period of HIV diagnosis (<1997/≥1997), and clinical center. The risk of fracture was analyzed with conditional logistic regression models, using different ways to model ARV exposure. All exposure variables and potential confounders wer...