Formal synthesis of (+)-lactacystin from L-serine

This investigation has enjoyed the support of Charnwood Molecular Ltd and the University of East Anglia.A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-L-serine, providing the key intermediate 13 , also useful for the generation of a range of C-9 analogues.Publisher PDFPeer reviewe