Beginning in the late 1980s, a small cohort of anthropologists and computer scientists at Xerox Palo Alto Research Center developed an interdisciplinary research program concerned with the design and use of information technologies. Our projects over the years joined ethnographies of work and technologies-in-use with design interventions. This talk briefly reviews this program of research, illustrated with specific examples. Our ethnographic approach is exemplified in an early research project on information and communications technologies-in-use within a particular workplace. This project led, among other things, to a reconceptualization of what makes up an "information system" that informed all of our subsequent work. The latter turned in...