Extracellular matrix (hMatrix) derived from osteogenically enhanced mesenchymal stem cells (OEhMSCs) can be deposited onto scaffolds in a process referred to as “bioconditioning”. While bioconditioned gelatin scaffolds have been shown to enhance stem cell retention and significantly accelerate repair of critical-sized bone defects, there is a need for alternative biofabrication methods that have greater clinical potential in bone regenerative therapies. Injectable delivery vehicles are desirable because of their ability to space-fill defects and form a continuous interface with existing bone. Herein, we report gelatin methacrylate (GelMA) microspheres fabricated using a custom 3D-printed coaxial flow focusing device. We demonstrate that OEh...
Epigenetic approaches using the histone deacetylase 2 and 3 inhibitor-MI192 have been reported to ac...
Aim. Innovative scaffolds are of paramount importance for bone grafting and re-growth. Distinct enha...
Craniofacial bone defects have poor outcomes under current treatments: implants become infected, loo...
Extracellular matrix (hMatrix) derived from osteogenically enhanced mesenchymal stem cells (OEhMSCs)...
Due to challenges associated with current clinical techniques used to treat bone defects, there has ...
The aim of this project was to investigate the in vitro osteogenic potential of human mesenchymal pr...
The demand of new strategies for the induction of bone regeneration is continuously increasing. Biom...
A pressing need exists to develop an improved bone replacement to treat the millions of non-union fr...
There are currently several commercialized products approved by the Food and Drug Administration and...
The conventional treatments for craniofacial bone defects currently are unsatisfactory due to severa...
Objective Design of bioactive scaffolds with osteogenic capacity is a central challenge in cell-base...
Abstract Currently, sustained in vivo delivery of active bone morphogenetic protein-2 (BMP-2) protei...
The ability to regenerate damaged skeletal tissue is a significant unmet need for an increasingly ag...
AbstractDesign criteria for tissue‐engineered materials in regenerative medicine include robust biol...
Large bone defects pose a significant clinical challenge currently lacking an adequate therapeutic s...
Epigenetic approaches using the histone deacetylase 2 and 3 inhibitor-MI192 have been reported to ac...
Aim. Innovative scaffolds are of paramount importance for bone grafting and re-growth. Distinct enha...
Craniofacial bone defects have poor outcomes under current treatments: implants become infected, loo...
Extracellular matrix (hMatrix) derived from osteogenically enhanced mesenchymal stem cells (OEhMSCs)...
Due to challenges associated with current clinical techniques used to treat bone defects, there has ...
The aim of this project was to investigate the in vitro osteogenic potential of human mesenchymal pr...
The demand of new strategies for the induction of bone regeneration is continuously increasing. Biom...
A pressing need exists to develop an improved bone replacement to treat the millions of non-union fr...
There are currently several commercialized products approved by the Food and Drug Administration and...
The conventional treatments for craniofacial bone defects currently are unsatisfactory due to severa...
Objective Design of bioactive scaffolds with osteogenic capacity is a central challenge in cell-base...
Abstract Currently, sustained in vivo delivery of active bone morphogenetic protein-2 (BMP-2) protei...
The ability to regenerate damaged skeletal tissue is a significant unmet need for an increasingly ag...
AbstractDesign criteria for tissue‐engineered materials in regenerative medicine include robust biol...
Large bone defects pose a significant clinical challenge currently lacking an adequate therapeutic s...
Epigenetic approaches using the histone deacetylase 2 and 3 inhibitor-MI192 have been reported to ac...
Aim. Innovative scaffolds are of paramount importance for bone grafting and re-growth. Distinct enha...
Craniofacial bone defects have poor outcomes under current treatments: implants become infected, loo...