A trans-ancestral meta-analysis of Genome-wide Association Studies reveals loci associated with childhood obesity
- Bradfield, JP
- Vogelezang, S
- Felix, JF
- Chesi, A
- Helgeland, Ø
- Horikoshi, M
- Karhunen, V
- Lowry, E
- Cousminer, DL
- Ahluwalia, TS
- Thiering, E
- Boh, ET-H
- Zafarmand, MH
- Vilor-Tejedor, N
- Wang, CA
- Joro, R
- Chen, Z
- Gauderman, WJ
- Pitkänen, N
- Parra, EJ
- Fernandez-Rhodes, L
- Alyass, A
- Monnereau, C
- Curtin, JA
- Have, CT
- McCormack, SE
- Hollensted, M
- Frithioff-Bøjsøe, C
- Valladares-Salgado, A
- Peralta-Romero, J
- Teo, Y-Y
- Standl, M
- Leinonen, JT
- Holm, J-C
- Peters, T
- Vioque, J
- Vrijheid, M
- Simpson, A
- Custovic, A
- Vaudel, M
- Canouil, M
- Lindi, V
- Atalay, M
- Kähönen, M
- Raitakari, OT
- Van Schaik, BDC
- Berkowitz, RI
- Cole, SA
- Voruganti, VS
- Wang, Y
- Highland, HM
- Comuzzie, AG
- Butte, NF
- Justice, AE
- Gahagan, S
- Blanco, E
- Lehtimäki, T
- Lakka, TA
- Hebebrand, J
- Bonnefond, A
- Grarup, N
- Froguel, P
- Lyytikäinen, L-P
- Cruz, M
- Kobes, S
- Hanson, RL
- Zemel, BS
- Hinney, A
- Teo, KK
- Meyre, D
- North, KE
- Gilliland, FD
- Bisgaard, H
- Bustamante, M
- Bonnelykke, K
- Pennell, CE
- Rivadeneira, F
- Uitterlinden, AG
- Baier, LJ
- Vrijkotte, TGM
- Heinrich, J
- Sørensen, TIA
- Saw, S-M
- Pedersen, O
- Hansen, T
- Eriksson, J
- Widén, E
- McCarthy, MI
- Njølstad, PR
- Power, C
- Hyppönen, E
- Sebert, S
- Brown, CD
- Järvelin, M-R
- Timpson, NJ
- Johansson, S
- Hakonarson, H
- Jaddoe, VWV
- Grant, SFA
- Early Growth Genetics Consortium
DOIAbstract
Although hundreds of GWAS-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity, and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of thirty studies consisting of up to 13,005 cases (≥95th percentile of BMI achieved 2-18 years old) and 15,599 controls (consistently <50th percentile of BMI) of European, African, North/South American and East Asian ancestry. Suggestive loci were taken forward for replication in a sample of 1,888 cases and 4,689 controls from seven cohorts of European and North/South American ancestry. ...
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