RIFM fragrance ingredient safety assessment, methyl 2-nonenoate, CAS Registry Number 111-79-5
- Api, A.M.
- Belmonte, F.
- Belsito, D.
- Botelho, D.
- Bruze, M.
- Burton, G.A.
- Buschmann, J.
- Dagli, M.L.
- Date, M.
- Dekant, W.
- Deodhar, C.
- Fryer, A.D.
- Gadhia, S.
- Jones, L.
- Joshi, K.
- Cava, S. La
- Lapczynski, A.
- Lavelle, M.
- Liebler, D.C.
- Na, M.
- O'Brien, D.
- Penning, T.M.
- Ritacco, G.
- Romine, J.
- Sadekar, N.
- Salvito, D.
- Schultz, T.W.
- Sipes, I.G.
- Sullivan, G.
- Thakkar, Y.
- Tokura, Y.
- Tsang, S.
DOIAbstract
The existing information supports the use of this material as described in this safety assessment. Methyl 2-nonenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog ethyl trans-2,cis-4-decadienoate (CAS # 3025-30-7) show that methyl 2-nonenoate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to methyl 2-nonenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). Data from the target and read-across analog isobu...
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