© 2018 Halliday et al. http://creativecommons.org/licenses/by/4.0/ Wilms tumour is a childhood tumour that arises as a consequence of somatic and rare germline mutations, the characterisation of which has refined our understanding of nephrogenesis and carcinogenesis. Here we report that germline loss of function mutations in TRIM28 predispose children to Wilms tumour. Loss of function of this transcriptional co-repressor, which has a role in nephrogenesis, has not previously been associated with cancer. Inactivation of TRIM28, either germline or somatic, occurred through inactivating mutations, loss of heterozygosity or epigenetic silencing. TRIM28-mutated tumours had a monomorphic epithelial histology that is uncommon for Wilms tumour. Cri...
Wilms' tumor or nephroblastoma (WT), one of the most common childhood solid tumors (1:10,000, 8% of ...
AbstractWilms tumors (WT) have provided broad insights into the interface between development and tu...
The constitutional chromosomal deletion within the short arm of one copy of chromosome 11, at band p...
Wilms tumour is a childhood tumour that arises as a consequence of somatic and rare germline mutatio...
<div><p>Wilms tumour is a childhood tumour that arises as a consequence of somatic and rare germline...
Wilms tumors (WTs) are histologically diverse childhood cancers with variable contributions of blast...
Two percent of patients with Wilms tumors have a positive family history. In many of these cases the...
This study explores the genomic alterations that contribute to the formation of a unique subset of l...
This study explores the genomic alterations that contribute to the formation of a unique subset of l...
BACKGROUND: Wilms tumour is the most common childhood renal cancer and is genetically heterogeneous....
Wilms tumor, a childhood tumor arising from undifferentiated renal mesenchyme, is diagnosed in North...
To the Editor: Wilms tumor (WT), the most frequent pediatric renal tumor, primarily occurs as a spor...
Wilms tumors (WT) have provided broad insights into the interface between development and tumorigene...
Wilms tumour is an embryonal tumour of childhood that closely resembles the developing kidney. Genom...
Wilms' tumor, a childhood malignancy of the kidney, is one of the most common pediatric tumors. The ...
Wilms' tumor or nephroblastoma (WT), one of the most common childhood solid tumors (1:10,000, 8% of ...
AbstractWilms tumors (WT) have provided broad insights into the interface between development and tu...
The constitutional chromosomal deletion within the short arm of one copy of chromosome 11, at band p...
Wilms tumour is a childhood tumour that arises as a consequence of somatic and rare germline mutatio...
<div><p>Wilms tumour is a childhood tumour that arises as a consequence of somatic and rare germline...
Wilms tumors (WTs) are histologically diverse childhood cancers with variable contributions of blast...
Two percent of patients with Wilms tumors have a positive family history. In many of these cases the...
This study explores the genomic alterations that contribute to the formation of a unique subset of l...
This study explores the genomic alterations that contribute to the formation of a unique subset of l...
BACKGROUND: Wilms tumour is the most common childhood renal cancer and is genetically heterogeneous....
Wilms tumor, a childhood tumor arising from undifferentiated renal mesenchyme, is diagnosed in North...
To the Editor: Wilms tumor (WT), the most frequent pediatric renal tumor, primarily occurs as a spor...
Wilms tumors (WT) have provided broad insights into the interface between development and tumorigene...
Wilms tumour is an embryonal tumour of childhood that closely resembles the developing kidney. Genom...
Wilms' tumor, a childhood malignancy of the kidney, is one of the most common pediatric tumors. The ...
Wilms' tumor or nephroblastoma (WT), one of the most common childhood solid tumors (1:10,000, 8% of ...
AbstractWilms tumors (WT) have provided broad insights into the interface between development and tu...
The constitutional chromosomal deletion within the short arm of one copy of chromosome 11, at band p...