Influence of surface composition on the colloidal stability of ultra-small detonation nanodiamonds in biological media
- Bradac, C
- Rastogi, ID
- Cordina, NM
- Garcia-Bennett, A
- Brown, LJ
DOIAbstract
© 2018 Fluorescent nanodiamonds (NDs) are strong contenders as bio-labels for life science imaging, diagnostics and therapeutics. Ultimately, for their use in biomedical applications, their size should ideally be <10 nm. Yet, even more critical for their specificity and efficient uptake in cellular systems, is their resilience to aggregation, which is dictated by their colloidal stability in complex, physiological environments. To this end, we characterize small detonation NDs (~5 nm) by examining their surface chemical profiles and stability in solutions of varying ionic strength and pH. Using dynamic light scattering measurements, we demonstrate that small monodisperse ND particles with chemically homogeneous and negatively charged surfac...
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