Impact of uncertainties in exposure assessment on estimates of thyroid cancer risk among Ukrainian children and adolescents exposed from the chernobyl accident
- Little, MP
- Kukush, AG
- Masiuk, SV
- Shklyar, S
- Carroll, RJ
- Lubin, JH
- Kwon, D
- Brenner, AV
- Tronko, MD
- Mabuchi, K
- Bogdanova, TI
- Hatch, M
- Zablotska, LB
- Tereshchenko, VP
- Ostroumova, E
- Bouville, AC
- Drozdovitch, V
- Chepurny, MI
- Kovgan, LN
- Simon, SL
- Shpak, VM
- Likhtarev, IA
DOIAbstract
The 1986 accident at the Chernobyl nuclear power plant remains the most serious nuclear accident in history, and excess thyroid cancers, particularly among those exposed to releases of iodine-131 remain the best-documented sequelae. Failure to take dose-measurement error into account can lead to bias in assessments of dose-response slope. Although risks in the Ukrainian-US thyroid screening study have been previously evaluated, errors in dose assessments have not been addressed hitherto. Dose-response patterns were examined in a thyroid screening prevalence cohort of 13,127 persons aged <18 at the time of the accident who were resident in the most radioactively contaminated regions of Ukraine. We extended earlier analyses in this cohort by ...
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