The inhibition constants (Ki) of DNA-dependent RNA polymerase B (or II) from calf thymus were measured for eight synthetically obtained bicyclic amanitin-like thioethers, two R-sulfoxides, and two S-sulfoxides. These Ki values were compared with those of alpha-amanitin, its 6'-O-methylether Ia (an R-sulfoxide), the S-sulfoxide, the sulfone, the S-deoxo derivative (Id) of Ia, and several previously described amatoxins. The necessity of a beta-methyl side chain in position 3 and a hydroxy group in proline-2 was confirmed. Additionally, the presence of an isoleucine side chain in position 6 and the absence of a side chain in position 5 was recognized as important for binding to the enzyme. In the three sulfoxide samples examined, the R-diaster...
AbstractQuantitative effects of inhibitors of the replicative DNA polymerases (pol) α, δ and ϵ from ...
RNA polymerase, purified by a modification of the method of Furth, Hurwitz and Anders (1962) and Mai...
The effect of substitution of l and d amino acids in amatoxin analogues is discussed in this paper. ...
The amatoxins, highly toxic components of death cap Amanita mushrooms, bind strongly to RNA polymera...
The amatoxins, highly toxic components of Amanita mushrooms, strongly inhibit the DNA-dependent RNA ...
Four amatoxin-binding proteins with KD values in the nanomolar range, 3 monoclonal antibodies and RN...
The title compound 3, an amatoxin analogue containing l--aminobutyric acid instead of l-asparagine i...
The template-directed synthesis of a single phosphodiester bond by highly purified calf thymus RNA p...
Yeast ribonucleic acid (RNA) polymerase II, isolated after fractionation on diethylaminoethyl (DEAE)...
In an attempt to establish which RNA polymerase catalyzes the synthesis of the low molecular weight ...
Analogs of amaninamide, due to the absence of a 6-hydroxy group in the tryptophan moiety, are more e...
The amatoxins are a family of toxic bicyclic peptides that inhibit RNA polymerase II. Herein we disc...
Synthetic nucleosides and purine analogs have been used to study the catalytic activity of DNA-depen...
Ile3-amaninamide (3-R) and its diastereomeric sulfoxide (3-S) are obtained by oxidation of the bicyc...
Amatoxins are bicyclic peptides found in the Amanita mushroom species; these molecules are specific ...
AbstractQuantitative effects of inhibitors of the replicative DNA polymerases (pol) α, δ and ϵ from ...
RNA polymerase, purified by a modification of the method of Furth, Hurwitz and Anders (1962) and Mai...
The effect of substitution of l and d amino acids in amatoxin analogues is discussed in this paper. ...
The amatoxins, highly toxic components of death cap Amanita mushrooms, bind strongly to RNA polymera...
The amatoxins, highly toxic components of Amanita mushrooms, strongly inhibit the DNA-dependent RNA ...
Four amatoxin-binding proteins with KD values in the nanomolar range, 3 monoclonal antibodies and RN...
The title compound 3, an amatoxin analogue containing l--aminobutyric acid instead of l-asparagine i...
The template-directed synthesis of a single phosphodiester bond by highly purified calf thymus RNA p...
Yeast ribonucleic acid (RNA) polymerase II, isolated after fractionation on diethylaminoethyl (DEAE)...
In an attempt to establish which RNA polymerase catalyzes the synthesis of the low molecular weight ...
Analogs of amaninamide, due to the absence of a 6-hydroxy group in the tryptophan moiety, are more e...
The amatoxins are a family of toxic bicyclic peptides that inhibit RNA polymerase II. Herein we disc...
Synthetic nucleosides and purine analogs have been used to study the catalytic activity of DNA-depen...
Ile3-amaninamide (3-R) and its diastereomeric sulfoxide (3-S) are obtained by oxidation of the bicyc...
Amatoxins are bicyclic peptides found in the Amanita mushroom species; these molecules are specific ...
AbstractQuantitative effects of inhibitors of the replicative DNA polymerases (pol) α, δ and ϵ from ...
RNA polymerase, purified by a modification of the method of Furth, Hurwitz and Anders (1962) and Mai...
The effect of substitution of l and d amino acids in amatoxin analogues is discussed in this paper. ...