To initiate X-Chromosome inactivation (XCI), the long noncoding RNA Xist mediates chromosome-wide gene silencing of one X Chromosome in female mammals to equalize gene dosage between the sexes. The efficiency of gene silencing is highly variable across genes, with some genes even escaping XCI in somatic cells. A gene's susceptibility to Xist-mediated silencing appears to be determined by a complex interplay of epigenetic and genomic features; however, the underlying rules remain poorly understood. We have quantified chromosome-wide gene silencing kinetics at the level of the nascent transcriptome using allele-specific Precision nuclear Run-On sequencing (PRO-seq). We have developed a Random Forest machine-learning model that can predict the...
Despite decades of biochemical, proteomic and genetic characterizations of the Xist longnon-coding R...
The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that ...
During development, the precise relationships between transcription and chromatin modifications ofte...
To initiate X-Chromosome inactivation (XCI), the long noncoding RNA Xist mediates chromosome-wide ge...
Xist RNA, the master regulator of X chromosome inactivation, acts in cis to induce chromosome-wide s...
X chromosome inactivation (XCI) ensures an equal gene dosage between the sexes in placental mammals....
X chromosome inactivation (XCI) is a process by which one X chromosome in female mammals is silenced...
X-chromosome inactivation ensures equal expression of mammalian male and female X-linked genes by tr...
Background: During early embryonic development, one of the two X chromosomes in mammalian female cel...
Xist, X chromosome inactivation, XCI, genomic repeats, LINEsBackground. X chromosome inactivation, t...
The long non-coding RNA Xist exploits numerous effector proteins to progressively induce gene silenc...
SummaryX-chromosome inactivation is the process that evolved in mammals to equalize levels of X-link...
In female mammals, one of the two X chromosomes becomes genetically silenced to compensate for dosag...
X Chromosome Inactivation (XCI) is an example of dosage compensation in mammals in which one of the ...
BACKGROUND: X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked ...
Despite decades of biochemical, proteomic and genetic characterizations of the Xist longnon-coding R...
The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that ...
During development, the precise relationships between transcription and chromatin modifications ofte...
To initiate X-Chromosome inactivation (XCI), the long noncoding RNA Xist mediates chromosome-wide ge...
Xist RNA, the master regulator of X chromosome inactivation, acts in cis to induce chromosome-wide s...
X chromosome inactivation (XCI) ensures an equal gene dosage between the sexes in placental mammals....
X chromosome inactivation (XCI) is a process by which one X chromosome in female mammals is silenced...
X-chromosome inactivation ensures equal expression of mammalian male and female X-linked genes by tr...
Background: During early embryonic development, one of the two X chromosomes in mammalian female cel...
Xist, X chromosome inactivation, XCI, genomic repeats, LINEsBackground. X chromosome inactivation, t...
The long non-coding RNA Xist exploits numerous effector proteins to progressively induce gene silenc...
SummaryX-chromosome inactivation is the process that evolved in mammals to equalize levels of X-link...
In female mammals, one of the two X chromosomes becomes genetically silenced to compensate for dosag...
X Chromosome Inactivation (XCI) is an example of dosage compensation in mammals in which one of the ...
BACKGROUND: X chromosome inactivation, the mechanism used by mammals to equalise dosage of X-linked ...
Despite decades of biochemical, proteomic and genetic characterizations of the Xist longnon-coding R...
The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that ...
During development, the precise relationships between transcription and chromatin modifications ofte...