Platinum-containing molecules are widely used as anticancer drugs. These molecules exert cytotoxic effects by binding to DNA through various mechanisms. The binding between DNA and platinum-based drugs hinders the opening of DNA, and therefore, DNA duplication and transcription are severely hampered. Overall, impeding the above-mentioned important DNA mechanisms results in irreversible DNA damage and the induction of apoptosis. Several molecules, including multinuclear platinum compounds, belong to the family of platinum drugs, and there is a body of research devoted to developing more efficient and less toxic versions of these compounds. In this study, we combined different biophysical methods, including single-molecule assays (magnetic tw...
AbstractClinically ineffective transplatin [trans-diamminedichloridoplatinum(II)] is used in the stu...
The interaction of the widely used anticancer drug cisplatin with DNA bases was studied by EXAFS and...
The complex cis-dichlorodiammineplatinum(II) (DDP) is an active antitumor drug while the trans-DDP i...
Platinum-containing molecules are widely used as anticancer drugs. These molecules exert cytotoxic e...
Here we report a new study performed at single molecule level on the interaction of the antineoplast...
This work deals with studying a molecular mechanism of anticancer effect of a new platinum - based d...
Hybrid QM/MM calculations on adducts of five platinum-based anti-cancer drugs, namely cisplatin, oxa...
This study reports a detailed biophysical analysis of the DNA binding and cytotoxicity of six platin...
In the present work we have gone a step forward in the understanding of the DNA-cisplatin interactio...
Platinum anticancer drugs inhibit the division of cancer cells through a DNA binding mechanism. The ...
Cisplatin, cis-[PtCl2(NH3)2], is an anti-cancer drug that can be used in the treatment of various ty...
Abstract — Important features of DNA structure and the reactions of plati— num complexes with solven...
Cisplatin is widely used in clinic treatment against a variety of cancer diseases. It binds to two a...
The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent...
The kinetics and mechanism of DNA platinization reactions with the detection of platinization sites ...
AbstractClinically ineffective transplatin [trans-diamminedichloridoplatinum(II)] is used in the stu...
The interaction of the widely used anticancer drug cisplatin with DNA bases was studied by EXAFS and...
The complex cis-dichlorodiammineplatinum(II) (DDP) is an active antitumor drug while the trans-DDP i...
Platinum-containing molecules are widely used as anticancer drugs. These molecules exert cytotoxic e...
Here we report a new study performed at single molecule level on the interaction of the antineoplast...
This work deals with studying a molecular mechanism of anticancer effect of a new platinum - based d...
Hybrid QM/MM calculations on adducts of five platinum-based anti-cancer drugs, namely cisplatin, oxa...
This study reports a detailed biophysical analysis of the DNA binding and cytotoxicity of six platin...
In the present work we have gone a step forward in the understanding of the DNA-cisplatin interactio...
Platinum anticancer drugs inhibit the division of cancer cells through a DNA binding mechanism. The ...
Cisplatin, cis-[PtCl2(NH3)2], is an anti-cancer drug that can be used in the treatment of various ty...
Abstract — Important features of DNA structure and the reactions of plati— num complexes with solven...
Cisplatin is widely used in clinic treatment against a variety of cancer diseases. It binds to two a...
The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent...
The kinetics and mechanism of DNA platinization reactions with the detection of platinization sites ...
AbstractClinically ineffective transplatin [trans-diamminedichloridoplatinum(II)] is used in the stu...
The interaction of the widely used anticancer drug cisplatin with DNA bases was studied by EXAFS and...
The complex cis-dichlorodiammineplatinum(II) (DDP) is an active antitumor drug while the trans-DDP i...