An economic analysis of immediate delivery and expectant monitoring in women with hypertensive disorders of pregnancy, between 34 and 37 weeks of gestation (HYPITAT-II)

Objective To assess the economic consequences of immediate delivery compared with expectant monitoring in women with preterm non-severe hypertensive disorders of pregnancy.Design A cost-effectiveness analysis alongside a randomised controlled trial (HYPITAT-II).Setting Obstetric departments of seven academic hospitals and 44 non-academic hospitals in the Netherlands.Population Women diagnosed with non-severe hypertensive disorders of pregnancy between 34(0/7) and 37(0/7) weeks of gestation, randomly allocated to either immediate delivery or expectant monitoring.Methods A trial-based cost-effectiveness analysis was performed from a healthcare perspective until final maternal and neonatal discharge.Main outcome measures Health outcomes were expressed as the prevalence of respiratory distress syndrome, defined as the need for supplemental oxygen for >24 hours combined with radiographic findings typical for respiratory distress syndrome. Costs were estimated from a healthcare perspective until maternal and neonatal discharge.Results The average costs of immediate delivery (n = 352) were (sic)10 245 versus (sic)9563 for expectant monitoring (n = 351), with an average difference of (sic)682 (95% confidence interval, 95% CI -(sic)618 to (sic)2126). This 7% difference predominantly originated from the neonatal admissions, which were (sic)5672 in the immediate delivery arm and (sic)3929 in the expectant monitoring arm.Conclusion In women with mild hypertensive disorders between 34(0/7) and 37(0/7) weeks of gestation, immediate delivery is more costly than expectant monitoring as a result of differences in neonatal admissions. These findings support expectant monitoring, as the clinical outcomes of the trial demonstrated that expectant monitoring reduced respiratory distress syndrome for a slightly increased risk of maternal complications.