Background Vascular calcification in humans is associated with an increased cardiovascular risk. Carboxylated matrix Gla protein (cMGP) inhibits vascular calcification. Vitamin K is an essential cofactor for the activation of uncarboxylated matrix Gla protein (ucMGP). It has been suggested that patients on long-term treatment with vitamin K antagonists develop aortic valve calcifications because of lower levels of circulating MGP. We therefore hypothesized that arterial calcification and a low vitamin K status are associated with ucMGP. To that aim, we measured arterial calcium scores, the osteocalcin ratio (OCR), as a proxy for vitamin K status, and ucMGP. Materials and methods In 36 hypertensive patients, we determined the Agatston score ...
Vascular calcification is a marker of increased cardiovascular risk. Vitamin K-dependent matrix Gla ...
Vitamin K dependent proteins (VKDP), such as hepatic coagulation factors and vascular matrix Gla pro...
Vitamin K dependent proteins (VKDP), such as hepatic coagulation factors and vascular matrix Gla pro...
Background Vascular calcification in humans is associated with an increased cardiovascular risk. Car...
Matrix Gla protein (MGP) is a vitamin K-dependent protein and an inhibitor of vascular calcification...
Objectives Vitamin K plays a pivotal role in the synthesis of Matrix Gla protein (MGP), a calcificat...
Matrix Gla protein (MGP) is a calcification inhibitor in vascular tissue that must be carboxylated b...
We investigated the role of MGP carboxylation (i.e. activation) in the association of high vitamin K...
Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent ...
Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla prot...
Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla prot...
Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla prot...
OBJECTIVE: Matrix gamma-carboxyglutamate (Gla) protein (MGP) is a vitamin K-dependent protein and a ...
Vascular calcification is a marker of increased cardiovascular risk. Vitamin K-dependent matrix Gla ...
Vitamin K dependent proteins (VKDP), such as hepatic coagulation factors and vascular matrix Gla pro...
Vitamin K dependent proteins (VKDP), such as hepatic coagulation factors and vascular matrix Gla pro...
Background Vascular calcification in humans is associated with an increased cardiovascular risk. Car...
Matrix Gla protein (MGP) is a vitamin K-dependent protein and an inhibitor of vascular calcification...
Objectives Vitamin K plays a pivotal role in the synthesis of Matrix Gla protein (MGP), a calcificat...
Matrix Gla protein (MGP) is a calcification inhibitor in vascular tissue that must be carboxylated b...
We investigated the role of MGP carboxylation (i.e. activation) in the association of high vitamin K...
Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent ...
Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla prot...
Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla prot...
Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla prot...
OBJECTIVE: Matrix gamma-carboxyglutamate (Gla) protein (MGP) is a vitamin K-dependent protein and a ...
Vascular calcification is a marker of increased cardiovascular risk. Vitamin K-dependent matrix Gla ...
Vitamin K dependent proteins (VKDP), such as hepatic coagulation factors and vascular matrix Gla pro...
Vitamin K dependent proteins (VKDP), such as hepatic coagulation factors and vascular matrix Gla pro...