The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to persist in the tick phase of its enzootic life cycle. We previously found that the stringent response mediated by RelBbu globally regulates gene expression to facilitate persistence in the tick vector. Here, we show that RelBbu regulates the expression of a swath of small RNAs (sRNA), affecting 36% of previously identified sRNAs in B. burgdorferi. This is the first sRNA regulatory mechanism identified in any spirochete. Threefold more sRNAs were RelBbu-upregulated than downregulated during nutrient stress and included antisense, intergenic and 5′ untranslated region sRNAs. RelBbu-regulated sRNAs associated with genes known to be important for hos...
The importance of gene regulation in the enzootic cycle of Borrelia burgdorferi, the spirochete that...
Post-transcriptional regulation via small regulatory RNAs (sRNAs) has been implicated in diverse reg...
Abstract Background Borrelia burgdorferi contains one 16S and two tandem sets of 23S-5S ribosomal (r...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to pers...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
The causative agent of Lyme disease Borrelia burgdorferi, is maintained in nature in an enzootic cyc...
Abstract Background Transmissi...
Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of Ly...
Borrelia burgdorferi, the causative agent of Lyme disease, survives in nature through a cycle that a...
Borrelia burgdorferi, the causative agent of Lyme disease, survives in nature through a cycle that a...
The importance of gene regulation in the enzootic cycle of Borrelia burgdorferi, the spirochete that...
Post-transcriptional regulation via small regulatory RNAs (sRNAs) has been implicated in diverse reg...
Abstract Background Borrelia burgdorferi contains one 16S and two tandem sets of 23S-5S ribosomal (r...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to pers...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
<p>The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to p...
The causative agent of Lyme disease Borrelia burgdorferi, is maintained in nature in an enzootic cyc...
Abstract Background Transmissi...
Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of Ly...
Borrelia burgdorferi, the causative agent of Lyme disease, survives in nature through a cycle that a...
Borrelia burgdorferi, the causative agent of Lyme disease, survives in nature through a cycle that a...
The importance of gene regulation in the enzootic cycle of Borrelia burgdorferi, the spirochete that...
Post-transcriptional regulation via small regulatory RNAs (sRNAs) has been implicated in diverse reg...
Abstract Background Borrelia burgdorferi contains one 16S and two tandem sets of 23S-5S ribosomal (r...