Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic Stroke
- Broderick, Joseph P.
- Berkhemer, Olvert A.
- Palesch, Yuko Y.
- Dippel, Diederik W. J.
- Foster, Lydia D.
- Roos, Yvo B. W. E. M.
- van der Lugt, Aad
- Tomsick, Thomas A.
- Majoie, Charles B. L. M.
- van Zwam, Wim H.
- Demchuk, Andrew M.
- van Oostenbrugge, Robert J.
- Khatri, Pooja
- Lingsma, Hester F.
- Hill, Michael D.
- Roozenbeek, Bob
- Jauch, Edward C.
- Jovin, Tudor G.
- Yan, Bernard
- von Kummer, Ruediger
- Molina, Carlos A.
- Goyal, Mayank
- Schonewille, Wouter J.
- Mazighi, Mikael
- Engelter, Stefan T.
- Anderson, Craig S.
- Spilker, Judith
- Carrozzella, Janice
- Ryckborst, Karla J.
- Janis, L. Scott
- Simpson, Kit N.
Publication date
December 2015
DOIAbstract
Background and Purpose-We assessed the effect of endovascular treatment in acute ischemic stroke patients with severe neurological deficit (National Institutes of Health Stroke Scale score, >= 20) after a prespecified analysis plan. Methods-The pooled analysis of the Interventional Management of Stroke III (IMS III) and Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) trials included participants with an National Institutes of Health Stroke Scale score of >= 20 before intravenous tissue-type plasminogen activator (tPA) treatment (IMS III) or randomization (MR CLEAN) who were treated with intravenous tP
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