Improved overall survival after contralateral risk-reducing mastectomy in brca1/2 mutation carriers with a history of unilateral breast cancer: A prospective analysis
- Heemskerk-Gerritsen, Bernadette A. M.
- Rookus, Matti A.
- Aalfs, Cora M.
- Ausems, Margreet G. E. M.
- Collee, Johanna M.
- Jansen, Liesbeth
- Kets, C. Marleen
- Keymeulen, Kristien B. M. I.
- Koppert, Linetta B.
- Meijers-Heijboer, Hanne E. J.
- Mooij, Thea M.
- Tollenaar, Rob A. E. M.
- Vasen, Hans F. A.
- Hooning, Maartje J.
- Seynaeve, Caroline
DOIAbstract
Data on survival of BRCA1/2-associated primary breast cancer (PBC) patients who opt for subsequent contralateral risk-reducing mastectomy (CRRM) are scarce and inconsistent. We examined the efficacy of CRRM on overall survival in mutation carriers with a history of PBC. From a Dutch multicentre cohort, we selected 583 BRCA-associated PBC patients, being diagnosed between 1980 and 2011. Over time, 242 patients (42%) underwent CRRM and 341 patients (58%) remained under surveillance. Survival analyses were performed using Cox models, with CRRM as a time-dependent covariate. The median follow-up after PBC diagnosis was 11.4 years. In the CRRM group, four patients developed contralateral breast cancer (2%), against 64 patients (19%) in the surve...
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