Background Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and COPD severity. Previous genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with the number of cigarettes smoked per day (CPD) and a dopamine beta-hydroxylase (DBH) locus associated with smoking cessation in multiple populations. Objective To identify SNPs associated with lifetime average and current CPD, age at smoking initiation, and smoking cessation in patients with COPD. Methods GWAS were conducted in four independent cohorts encompassing 3441 ever-smoking patients with COPD (Global Initiative for Obstructive Lung Disease stage II or higher). Untyped SNPs were imputed usi...
Risk for Chronic Obstructive Pulmonary Disease (COPD) is determined by both cigarette smoking and ge...
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pu...
Genome-wide association studies identified single nucleotide polymorphisms (SNPs) in the nicotinic a...
Background Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD)...
Abstract Background Smoking is the principal modifiable environmental risk factor for chronic obstru...
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pu...
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pu...
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pu...
Cigarette smoking is one of the major risk factors for COPD and COPD severity. In turn COPD is a maj...
The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely unknown....
The contribution of common genetic variation to one or more established smoking behaviors was invest...
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide; the main...
Risk for Chronic Obstructive Pulmonary Disease (COPD) is determined by both cigarette smoking and ge...
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pu...
Genome-wide association studies identified single nucleotide polymorphisms (SNPs) in the nicotinic a...
Background Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD)...
Abstract Background Smoking is the principal modifiable environmental risk factor for chronic obstru...
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pu...
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pu...
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pu...
Cigarette smoking is one of the major risk factors for COPD and COPD severity. In turn COPD is a maj...
The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely unknown....
The contribution of common genetic variation to one or more established smoking behaviors was invest...
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide; the main...
Risk for Chronic Obstructive Pulmonary Disease (COPD) is determined by both cigarette smoking and ge...
There is considerable variability in the susceptibility of smokers to develop chronic obstructive pu...
Genome-wide association studies identified single nucleotide polymorphisms (SNPs) in the nicotinic a...