Add to ORKGDifferentiated pancreatic acinar cells expressing endogenous levels of mutant K-Ras do not spontaneously develop pancreatic ductal adenocarcinoma (PDAC). However, we hypothesized that acinar cells would develop PDAC in the presence of Ras activity levels mimicking those of human tumor cells.We measured Ras activity in PDAC cells from mice and humans using a Raf pull-down assay. We compared the effects of acinar cell expression of mutant K-Ras at endogenous and elevated levels on Ras activity and on the development of PDAC
The mechanism of tumorigenesis in the immortalized human pancreatic cell lines: cell culture models ...
SummaryPancreatic acinar cells of adult mice (≥P60) are resistant to transformation by some of the m...
<div><p>Activating K-RAS mutations occur at a frequency of 90% in pancreatic cancer, and to date no ...
SummaryPancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often involves so...
Pancreatic Ductal Adenocarcinoma (PDAC) is nearly always associated with mutant K-Ras. Nevertheless,...
SummaryPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To inve...
Rb1 encodes a cell-cycle regulator that is functionally disrupted in most human cancers. Pancreatic ...
BACKGROUND & AIMS: Activating mutation of the KRAS gene is common in some cancers, such as pancreati...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate...
SummaryPancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often involves so...
Background: The RAS family of small GTPases is comprised of HRAS, NRAS, and KRAS. KRAS is invariably...
Pancreatic duct ligation (PDL) in the murine model has been described as an exocrine pancreatic atro...
[[abstract]]Ras plays an essential role in the development of acinar to ductal metaplasia (ADM) and ...
BackgroundThe RAS family of small GTPases is comprised of HRAS, NRAS, and KRAS. KRAS is invariably o...
[[abstract]]Ras plays an essential role in the development of acinar to ductal metaplasia (ADM) and ...
The mechanism of tumorigenesis in the immortalized human pancreatic cell lines: cell culture models ...
SummaryPancreatic acinar cells of adult mice (≥P60) are resistant to transformation by some of the m...
<div><p>Activating K-RAS mutations occur at a frequency of 90% in pancreatic cancer, and to date no ...
SummaryPancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often involves so...
Pancreatic Ductal Adenocarcinoma (PDAC) is nearly always associated with mutant K-Ras. Nevertheless,...
SummaryPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To inve...
Rb1 encodes a cell-cycle regulator that is functionally disrupted in most human cancers. Pancreatic ...
BACKGROUND & AIMS: Activating mutation of the KRAS gene is common in some cancers, such as pancreati...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate...
SummaryPancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often involves so...
Background: The RAS family of small GTPases is comprised of HRAS, NRAS, and KRAS. KRAS is invariably...
Pancreatic duct ligation (PDL) in the murine model has been described as an exocrine pancreatic atro...
[[abstract]]Ras plays an essential role in the development of acinar to ductal metaplasia (ADM) and ...
BackgroundThe RAS family of small GTPases is comprised of HRAS, NRAS, and KRAS. KRAS is invariably o...
[[abstract]]Ras plays an essential role in the development of acinar to ductal metaplasia (ADM) and ...
The mechanism of tumorigenesis in the immortalized human pancreatic cell lines: cell culture models ...
SummaryPancreatic acinar cells of adult mice (≥P60) are resistant to transformation by some of the m...
<div><p>Activating K-RAS mutations occur at a frequency of 90% in pancreatic cancer, and to date no ...