Occupational exposure to Organophosphate Pesticides and its Effects on Human Sperm Parameters: A systematic Review

Background Previous research has indicated there is a decrease in sperm quality in the last 40 years. There have been a few reports that have associated occupational exposure to Organophosphate pesticides with a decrease in sperm count, abnormalities in the head or tail, and motility leading to infertility over time. Organophosphates are the most common pesticides used in the United States and have been classified as toxic to bees, wildlife, and humans by the EPA even at low exposures. Furthermore, Organophosphates are considered endocrine disrupting chemicals altering the normal function of the endocrine system. This occurs by interfering with the natural hormones the body produces due to their strong bind to estrogen and androgen receptors. Objective This systematic review sought to identify relevant studies evaluating the relationship of occupational exposure to Organophosphate pesticides and the decrease of sperm parameters in agriculture workers, pesticide sprayers, and farm workers worldwide. Methods PubMed, Scopus, Himmelfarb, and Agriculture Environmental Science databases were searched for all studies in English. Peer-reviewed articles were selected between the years of 2008 and 2016. Risk of bias was assessed according to the Navigation Guide a Systematic Review Methodology. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was utilized to rate the quality of evidence of each study. Results Five studies were identified, reviewed, and analyzed according to inclusion criteria. Selected studies were rated “low, probably low, not applicable, probably high risk, and high risk” for risk of bias. Studies were assigned a “low quality” rating for strength of evidence. Grey literature was excluded. Conclusion There is sufficient evidence that supports a positive association between occupational Organophosphate exposure and a decrease of sperm parameters in agriculture workers, pesticide sprayers, and farm workers worldwide. Sperm analysis demonstrated a decrease in sperm volume, motility, quality of sperm, and DNA damage, however, future studies are needed to explore this association further