BACKGROUND: Newly developed white matter (WM) injury is common after cardiopulmonary bypass (CPB) in severe/complex congenital heart disease. Fractional anisotropy (FA) allows measurement of macroscopic organization of WM pathology but has rarely been applied after CPB. The aims of our animal study were to define CPB-induced FA alterations and to determine correlations between these changes and cellular events after congenital heart disease surgery. METHODS AND RESULTS: Normal porcine WM development was first assessed between 3 and 7 weeks of age: 3-week-old piglets were randomly assigned to 1 of 3 CPB-induced insults. FA was analyzed in 31 WM structures. WM oligodendrocytes, astrocytes, and microglia were assessed immunohistologically. Nor...
ObjectiveTo determine the relationship between radiologically identifiable brain injuries and delaye...
ObjectivesWe performed a regional volumetric study of the brain using 3-dimensional magnetic resonan...
Patients with complex congenital heart disease are at risk for neurodevelopmental impairments. Evide...
BACKGROUND Mortality and morbidity in the severe/complex congenital heart disease population have be...
Congenital heart disease (CHD) is the leading birth defect, affecting almost 1% of births each year....
Background: Brain microstructural maturation progresses rapidly in the third trimester of gestation ...
Background: Brain microstructural maturation progresses rapidly in the third trimester of gestation ...
Background: Brain microstructural maturation progresses rapidly in the third trimester of gestation ...
ObjectiveOur objective was to use diffusion tensor imaging (DTI) to compare white matter microstruct...
ObjectiveCerebral white matter (WM) injury is common after cardiac surgery in neonates and young inf...
Congenital heart disease (CHD) patients are at risk for alterations in the cerebral white matter mic...
BACKGROUND AND PURPOSE:Neonates with severe CHD require CPB within the first days of life. White mat...
Patients with complex congenital heart disease are at risk for neurodevelopmental impairments. Evide...
Introduction Congenital heart diseases is the leading birth defect, affecting almost 1% of births e...
ObjectiveWe investigated whether the degree of vulnerability of different areas in the developing br...
ObjectiveTo determine the relationship between radiologically identifiable brain injuries and delaye...
ObjectivesWe performed a regional volumetric study of the brain using 3-dimensional magnetic resonan...
Patients with complex congenital heart disease are at risk for neurodevelopmental impairments. Evide...
BACKGROUND Mortality and morbidity in the severe/complex congenital heart disease population have be...
Congenital heart disease (CHD) is the leading birth defect, affecting almost 1% of births each year....
Background: Brain microstructural maturation progresses rapidly in the third trimester of gestation ...
Background: Brain microstructural maturation progresses rapidly in the third trimester of gestation ...
Background: Brain microstructural maturation progresses rapidly in the third trimester of gestation ...
ObjectiveOur objective was to use diffusion tensor imaging (DTI) to compare white matter microstruct...
ObjectiveCerebral white matter (WM) injury is common after cardiac surgery in neonates and young inf...
Congenital heart disease (CHD) patients are at risk for alterations in the cerebral white matter mic...
BACKGROUND AND PURPOSE:Neonates with severe CHD require CPB within the first days of life. White mat...
Patients with complex congenital heart disease are at risk for neurodevelopmental impairments. Evide...
Introduction Congenital heart diseases is the leading birth defect, affecting almost 1% of births e...
ObjectiveWe investigated whether the degree of vulnerability of different areas in the developing br...
ObjectiveTo determine the relationship between radiologically identifiable brain injuries and delaye...
ObjectivesWe performed a regional volumetric study of the brain using 3-dimensional magnetic resonan...
Patients with complex congenital heart disease are at risk for neurodevelopmental impairments. Evide...